12 Selected Research Publications and 3 Reviews

Yi J, Zhu J, Wu J, Thompson CB, Jiang X. Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. PNAS 2020 (117):31189-31197. PMCID: PMC7733797

Zhang Z, Karthaus WR, Lee RS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Darnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X*, Watson PA*, Sawyers CL*. Tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer. Cancer Cell 2020 (38) 279-296. PMCID: PMC7472556 (*: co-corresponding authors)

Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN, Jiang X. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature 2019 Aug:572(7770):E20, PMCID: PMC6697195

Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, Jiang X. Role of mitochondria in ferroptosis. Molecular Cell 2019 (73):354-363. PMCID: PMC6338496

Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis Is an Autophagic Cell Death Process. Cell Research 2016 Sept 26(9):1021-32. PMCID: PMC5034113

Wong P, Feng Y, Wang J, Shi R, and Jiang X. Regulation of Autophagy by Coordinated Action of mTORC1 and Protein Phosphatase 2A. Nature Communications 2015 Aug 27; 6:8048. PMCID: PMC4552084

Gao M, Monian P, Quadri N, Ramasamy R, and Jiang X. Glutaminolysis and Transferrin Regulate Ferroptosis. Molecular Cell 2015 (59): 298-308. PMCID: PMC4506736

Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, Jiang X. PTEN Is a Protein Tyrosine Phosphatase for IRS1. Nat Struct. Mol. Biol. 2014 (21) 522-527. PMCID: PMC4167033

Gammoh N, Florey O, Overholtzer M, & Jiang X. Interaction Between FIP200 and ATG16L1 Distinguishes ULK1 Complex-Dependent and -Independent Autophagy. Nature Structural & Molecular Biology 2013 (20) 144-149. PMCID: PMC3565010

Feldman T, Kabaleeswaran, Jang S, Antczak C, Djaballah H, Wu H, Jiang X. A Class of Allosteric Caspase Inhibitors Identified by High-Throughput Screening. Molecular Cell 2012 (47) 585-595. PMCID: PMC3428514

Gammoh N, Lam D, Puente C, Ganley IG, Marks PA, Jiang X. Role of Autophagy in Histone Deacetylase Inhibitor-Induced Apoptotic and Non-Apoptotic Cell Death. Proc Natl Acad Sci U S A 2012 (109) 6561-6565. PMCID: PMC3340088

Ganley IG, Wong P-M, Gammoh N, Jiang X. Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest. Molecular Cell 2011 (42):731-743. PMCID: PMC3124681

Gao M, Jiang X. To Eat or Not to Eat – the Metabolic Flavor of Ferroptosis. Current Opinion in Cell Biology 2018 (51) 58-64. PMCID: PMC5949249. (Review).

Jiang X, Overholtzer M, Thompson C. Autophagy in Cellular Metabolism and Cancer. J. Clin. Invest. 2015 (125): 47-54. PMCID: PMC4382242. (Review).

Jiang X, Stockwell BR & Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 2021. 22(4):266-282.  (Review)