Thomas Norman: Publications

Thomas Norman: Publications


Smith, M.H., Gao, V.R., Schizas, M., Kochen, A., DiCarlo, E.F., Goodman, S.M., Norman, T.M., Donlin, L.T., Leslie, C.S., and A.Y. Rudensky. Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Nature Immunology 24, 1200–1210 (2023).

Replogle, J.M.*, Saunders, R.A.*, Pogson, A.N., Hussmann, J.A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E.J., Adelman, K., Bonnar, J.L., Jost, M., Norman, T.M.† and Jonathan S Weissman.† Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell vol. 185 2559-2575.e28 (2022).

Jost, M., Santos, D.A., Saunders, R.A., Horlbeck, M.A., Hawkins, J.S., Scaria, S.M., Norman, T.M., Hussmann, J.A., Liem, C.R., Gross, C.A. & Weissman, J.S. Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs. Nature Biotechnology 38, 355-364 (2020).

Replogle, J.M., Norman, T.M., Xu, A., Hussman, J.A., Chen, J., Cogan, Z.C., Meer, E.J., Terry, J.M, Riordan, D., Srinivas, N., Fiddes, I.T., Arthur, J., Alvarado, L.J., Pfeiffer, K.A., Mikkelsen, T.S., Weissman, J.S., & Adamson, B. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nature Biotechnology 38, 954-961 (2020).

Norman, T.M.* †, Horlbeck, M.*, Replogle, J., Ge, A., Xu, A., Jost, M., Gilbert, L., & Weissman, J.S†. Exploring genetic interaction manifolds constructed from rich phenotypes. Science 365, 786-793 (2019).

Lord, N.D.*, Norman, T.M.*, Yuan, R., Losick, R., & Paulsson, J. Stochastic antagonism between two proteins governs a bacterial cell fate switch. Science 366, 116–120 (2019).

Chan, M.*, Smith, Z.D.*, Grosswendt, S, Kretzmer, H, Norman, T., Adamson, B, Jost, M., Quinn, J.J., Yang, D., Meissner, A. & Weissman, J.S. Molecular recording of mammalian embryogenesis. Nature 570, 77-82 (2019).

Adamson, B.*, Norman, T.M.*, Jost, M., Cho, M.Y., Nuñez, J.K., Chen, Y., Villalta, J.E., Gilbert, L.A., Horlbeck, M.A., Hein, M.Y. Pak, R.A., Gray, A.N., Gross, C.A., Dixit, A. Parnas, O., Regev, A. & Weissman, J.S. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response. Cell 167, 1867-1882 (2016).

Dixit, A., Parnas, O., Li, B., Chen, J., Fulco, C.P., Jerby-Arnon, L., Marjanovic, N.D., Dionne, D., Burks, T., Raychowdhury, R., Adamson, B., Norman, T.M., Lander, E.S., Weissman, J.S., Friedman, N., & Regev, A. Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell 167, 1853-1866 (2016).

Hilfinger, A., Norman, T. & Paulsson, J. Exploiting natural fluctuations to identify kinetic mechanisms in sparsely characterized systems. Cell Systems 2, 251–259 (2016).

Hilfinger, A.*, Norman, T.*, Vinnicombe, G. & Paulsson, J. Constraints on fluctuations in sparsely characterized biological systems. Physical Review Letters 116, 058101 (2016).

Norman, T.*, Lord, N.*, Paulsson, J. & Losick, R. Memory and modularity in cell-fate decision making. Nature 503, 481–486 (2013).

Chai, Y., Norman, T., Kolter, R. & Losick, R. Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis. EMBO J. 30, 1402–1413 (2011).

Chai, Y., Norman, T., Kolter, R. & Losick, R. An epigenetic switch governing daughter cell separation in Bacillus subtilis. Genes & Development. 24, 754–765 (2010).

Chastanet, A., Vitkup, D., Yuan, G.C., Norman, T.M., Liu, J.S., & Losick, R. Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis. PNAS 107, 8486–8491 (2010).