Computational & Systems Biology Program
The Thomas Norman Lab
Research
![Thomas Norman](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/183361/person/norman_190926_08_3x2.jpg?h=10d202d3)
Assistant Professor
The Norman Lab aims to combine large-scale functional genomics experiments with computational modeling to enable rational engineering of cell state. Our primary model system is the fibroblast, a ubiquitous and phenotypically plastic cell type that plays a role in diverse pathologies. We played a foundational role in developing the Perturb-seq approach for single-cell CRISPR screening and continue to develop new approaches to enable functional genomics experiments beyond genome-scale. Our ultimate goal is to learn principles for precisely controlling cellular behavior, with potential applications in cell therapy and disease modeling.
![Tom Norman Lab](https://www.sloankettering.edu/sites/default/files/node/183361/images/tom-norman-lab-221018-6_rt_1200x800.jpg)
Publications Highlights
Replogle, J.M.*, Saunders, R.A.*, Pogson, A.N., Hussmann, J.A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E.J., Adelman, K., Bonnar, J.L., Jost, M., Norman, T.M.† and Jonathan S Weissman.† Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell vol. 185 2559-2575.e28 (2022).
Norman, T.M.*, Horlbeck, M.*, Replogle, J., Ge, A., Xu, A., Jost, M., Gilbert, L., & Weissman, J.S. Exploring genetic interaction manifolds constructed from rich phenotypes. Science 365, 786-793 (2019).
Adamson, B.*, Norman, T.M.*, Jost, M., Cho, M.Y., Nuñez, J.K., Chen, Y., Villalta, J.E., Gilbert, L.A., Horlbeck, M.A., Hein, M.Y. Pak, R.A., Gray, A.N., Gross, C.A., Dixit, A. Parnas, O., Regev, A. & Weissman, J.S. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response. Cell 167, 1867-1882 (2016).
People
![Thomas Norman](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/183361/person/norman_190926_08_3x2.jpg?h=10d202d3)
Thomas Norman, PhD
Assistant Professor
- Systems biologist Thomas Norman develops new computational and functional genomics approaches for studying how genes interact to realize complex phenotypes.
- PhD, Harvard University
- [email protected]
- Email Address
Members
![Rico Ardy](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/201157/main_image/ardy-rico_200827_03.jpg?h=242cd5c8)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/252176/main_image/unknown.jpeg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/207889/main_image/donnellan_180508_06_1200x800.jpg?h=10d202d3)
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![Olatunji Oni](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/201154/main_image/oni-olatunji_201207_03_1200x800.jpg)
![Kaden Southard](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/215185/main_image/southard-kaden_201207_06_1200x800.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/252181/main_image/tang-anran-221018-10.jpg)
![Rico Ardy](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/201157/main_image/ardy-rico_200827_03.jpg?h=242cd5c8)
Research Fellow
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/252176/main_image/unknown.jpeg)
Graduate Student
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Administrative Assistant, Sr.
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Graduate Student
![Olatunji Oni](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/201154/main_image/oni-olatunji_201207_03_1200x800.jpg)
Graduate Student
![Kaden Southard](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/215185/main_image/southard-kaden_201207_06_1200x800.jpg)
Research Scholar
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/252181/main_image/tang-anran-221018-10.jpg)
Graduate Student
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/252171/main_image/budhram-emily-221018-03_rt.jpg?h=242cd5c8)
Lab Alumni
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Research Technician
Laboratory Technician
Lab Affiliations
Achievements
- Josie Robertson Investigator (2019-2024)
- Damon Runyon-Dale F. Frey Award for Breakthrough Scientists (2019)
- Damon Runyon Cancer Research Foundation Fellowship (2015-2018)
- NIH Director's New Innovator Award (2020)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Thomas Norman discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].