Santosha Vardhana: Publications

Santosha Vardhana: Publications

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Kalish RB, Vardhana S, Gupta M, Chasen ST, Perni SC, Witkin SS. Interleukin-1 receptor antagonist gene polymorphism and multifetal pregnancy outcome. Am J Obstet Gynecol. 2003 Oct;189(4):911-4.

Witkin SS, Vardhana S, Yih M, Doh K, Bongiovanni AM, Gerber S. Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1beta and interleukin-1 receptor antagonist and pregnancy outcome. Am J Obstet Gynecol. 2003 Nov;189(5):1413-7.

Kalish RB, Vardhana S, Gupta M, Perni SC, Witkin SS. Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestations. Am J Obstet Gynecol. 2004 Mar;190(3):702-6.

Nguyen DP, Genc M, Vardhana S, Babula O, Onderdonk A, Witkin SS. Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women. Obstet Gynecol. 2004 Aug;104(2):293-300.

Genc MR, Vardhana S, Delaney ML, Onderdonk A, Tuomala R, Norwitz E, Witkin SS; MAP Study Group. Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women. Eur J Obstet Gynecol Reprod Biol. 2004 Oct 15;116(2):152-6.

Doh K, Sziller I, Vardhana S, Kovacs E, Papp Z, Witkin SS. Beta2-adrenergic receptor gene polymorphisms and pregnancy outcome. J Perinat Med. 2004;32(5):413-7.

Perni SC, Vardhana S, Tuttle SL, Kalish RB, Chasen ST, Witkin SS. Fetal interleukin-1 receptor antagonist gene polymorphism, intra-amniotic interleukin-1beta levels, and history of spontaneous abortion. Am J Obstet Gynecol. 2004 Oct;191(4):1318-23.

Genc MR, Onderdonk AB, Vardhana S, Delaney ML, Norwitz ER, Tuomala RE, Paraskevas LR, Witkin SS; MAP Study Group. Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth. Am J Obstet Gynecol. 2004 Oct;191(4):1324-30.

Kalish RB, Vardhana S, Gupta M, Perni SC, Chasen ST, Witkin SS. Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd  heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes. Am J Obstet Gynecol. 2004 Oct;191(4):1368-74.

Perni SC, Vardhana S, Korneeva I, Tuttle SL, Paraskevas LR, Chasen ST, Kalish RB, Witkin SS. Mycoplasma hominis and Ureaplasma urealyticum in midtrimester amniotic fluid: association with amniotic fluid cytokine levels and pregnancy outcome. Am J Obstet Gynecol. 2004 Oct;191(4):1382-6.

Kalish RB, Nguyen DP, Vardhana S, Gupta M, Perni SC, Witkin SS. A single nucleotide A>G polymorphism at position -670 in the Fas gene promoter: relationship to preterm premature rupture of fetal membranes in multifetal pregnancies. Am J Obstet Gynecol. 2005 Jan;192(1):208-12.

Gerber S, Vardhana S, Meagher-Villemure K, Vial Y, Hohlfeld P, Witkin SS. Association between fetal interleukin-1 receptor antagonist gene polymorphism and unexplained fetal death. Am J Obstet Gynecol. 2005 Oct;193(4):1472-7.

Perni SC, Vardhana S, Kalish R, Chasen S, Witkin SS. Clara cell protein 16 concentration in mid-trimester amniotic fluid: association with fetal gender, fetal G>A +38 CC16 gene polymorphism and pregnancy outcome. J Reprod Immunol. 2005 Dec;68(1-2):85-90.

Kalish RB, Vardhana S, Normand NJ, Gupta M, Witkin SS. Association of a maternal CD14 -159 gene polymorphism with preterm premature rupture of membranes and spontaneous preterm birth in multi-fetal pregnancies. J Reprod Immunol. 2006 Jun;70(1-2):109-17.

Genç MR, Vardhana S, Delaney ML, Witkin SS, Onderdonk AB; MAP Study Group. TNFA-308G>A polymorphism influences the TNF-alpha response to altered vaginal flora. Eur J Obstet Gynecol Reprod Biol. 2007 Oct;134(2):188-91.

Kirchhof MG, Chau LA, Lemke CD, Vardhana S, Darlington PJ, Márquez ME, Taylor R, Rizkalla K, Blanca I, Dustin ML, Madrenas J. Modulation of T cell activation by stomatin-like protein 2. J Immunol. 2008 Aug 1;181(3):1927-36.

Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML. T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol. 2008 Oct 1;181(7):4852-63.

Vardhana S, Dustin M. Supported Planar Bilayers for the Formation of Study of Immunological Synapses and Kinapse. J Vis Exp. 2008 Sep 15;(19).

Ilani T, Vasiliver-Shamis G, Vardhana S, Bretscher A, Dustin ML. T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol. 2009 May;10(5):531-9.

Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, Vale RD. The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol. 2009 May 4;185(3):521-34.

Srivastava S, Di L, Zhdanova O, Li Z, Vardhana S, Wan Q, Yan Y, Varma R, Backer J, Wulff H, Dustin ML, Skolnik EY. The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel Kca3.1 and CD4 T-cells. Mol Biol Cell. 2009 Sep;20(17):3783-91.

Chen HY, Fermin A, Vardhana S, Weng IC, Lo KF, Chang EY, Maverakis E, Yang RY, Hsu DK, Dustin ML, Liu FT. Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14496-501.

Vardhana S, Choudhuri K, Varma R, Dustin ML. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity. 2010 Apr 23;32(4):531-40.

Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW. Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med. 2012 Feb 13;209(2):335-52.

Christie DA, Kirchhof MG, Vardhana S, Dustin ML, Madrenas J. Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation. PloS One. 2012;7(5):e37144.

Kumari S, Vardhana S, Cammer M, Curado S, Santos L, Sheetz MP, Dustin ML. T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse. Front Immunol. 2012;3:230.

Waite JC, Vardhana S, Shaw PJ, Jang JE, McCarl CA, Cameron TO, Feske S, Dustin ML. Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo. Eur J Immunol. 2013; 43(12): 3343-54.

Satlin MJ, Vardhana S, Soave R, Shore TB, Mark TM, Jacobs SE, Walsh TJ, Gergis U. Impact of Prophylactic Levofloxacin on Rates of Bloodstream Infection and Fever in Neutropenic Patients with Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2015 Oct; 21(10): 1808-14.

Vardhana S, Sauter CS, Matasar MJ, Zelenetz AD, Galasso N, Woo KM, Zhang Z, Moskowitz CH. Outcomes of primary refractory diffuse large B-cell lymphoma (DLBCL) treated with salvage chemotherapy and intention to transplant in the rituximab era. Br J Haematol. 2017 Feb; 176(4): 591-599.

Finley LW*, Vardhana S* (co-first author), Carey BW*, Koche R, Chen Y, Alonso-Curbelo D, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB. Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nat Cell Biol. 2018 May; 20(5): 565-574.

Kumar A, Vardhana S, Moskowitz AJ, Porcu P, Dogan A, Dubovsky JA, Matasar MJ, Zhang Z, Younes A, Horwitz SM. Pilot Trial of Ibrutinib in patients with relapsed or refractory T-cell lymphoma. lood Adv. 2018 Apr 24; 2(8): 871-876.

Vardhana S, Hamlin PA, Yang J, Zelenetz A, Sauter CS, Matasar MJ, Ni A, Yahalom J, Moskowitz CH. Outcomes of relapsed and refractory primary mediastinal (thymic) diffuse large B-cell lymphoma treated with second-line therapy and intent to transplant. Biol Blood Marrow Transplant. 2018 Jun 15.

Vardhana S, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 2019 Jul;1(7):676-687.

Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W. Leveraging insights into cancer metabolism – a symposium report. Ann N Y Acad Sci. 2020 Feb;1462(1):5-13.

Maio M, Hamid O, Larkin J, Covre A, Altomonte M, Calabro L, Vardhana SA, Robert C, Ibrahim R, Anichini A, Wolchok JD, Giacomo AMD. Immune Checkpoint Inhibitors for Cancer Therapy in the COVID-19 Era. Clin Cancer Res. 2020 Jun 15. Doi: 10.11158/1078-0432.CCR-20-1657.

Vardhana S, Hwee M, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink M, Cross JR, Thompson CB. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T-cells exposed to persistent antigen. Nat Immunol 2020, July 13. Doi: 10.1038/s41590-020-0725-2.

Reviews

Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair DA, Waite J, Sacristán C, Victora GD, Zanin-Zhorov A, Dustin ML. Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol. 2010;28:79-105.

Vardhana S, Younes A. The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints. Haematologica. 2016 Jul; 101(7): 794-802.

Vardhana S, Cicero K, Velez MJ, Moskowitz CH. Strategies for Recognizing and Managing Immune-Mediated Adverse Events in the Treatment of Hodgkin Lymphoma with Checkpoint Inhibitors. Oncologist. 2019 Jan; 24(1): 86-95.

Schworer S, Vardhana S, Thompson CB. Cancer metabolism drives a stromal regenerative response. Cell Metab. 2019 Mar 5; 29(3): 576-591.

Vardhana S, Wolchok JD. The many faces of the anti-COVID immune response. J Exp Med 2020 June 1;217(6).