Human Oncology & Pathogenesis Program
The Santosha Vardhana Lab
The Vardhana lab explores how metabolites regulate immune cell homeostasis, particularly within tumors. We use a combination of traditional immunology, synthetic biology, metabolomics, and bioinformatics to answer fundamental biological questions about the regulation of immune responses with the goal of applying these strategies broadly for the treatment of cancer. Our team is made up of a diverse group of scientists and physicians with backgrounds in immunology, cancer biology, metabolism, and molecular genetics, but we are enthusiastic about integrating members with expertise across physical, life, and computer sciences to achieve our goal of taking novel experimental approaches to understand the complexity of host immunity.
Vardhana S, Hwee M, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink M, Cross JR, Thompson CB. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T-cells exposed to persistent antigen. Nat Immunol 2020, July 13. Doi: 10.1038/s41590-020-0725-2.
Vardhana S, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 2019 Jul;1(7):676-687.
Vardhana S, Choudhuri K, Varma R, Dustin ML. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity. 2010 Apr 23;32(4):531-40.
Santosha Vardhana, MD, PhD
- The Vardhana Lab studies how nutrient availability, uptake and metabolism regulates host immune responses during cancer development and immunotherapy.
- PhD, New York University
- Chief Medical Oncology Fellow, Internal Medicine, Memorial Sloan Kettering Cancer Center (2014)
- Young Investigator Award, American Society of Clinical Oncology (2016)
- Senior Fellow, Parker Institute of Cancer Immunotherapy (2017)
- Burroughs Wellcome Fund Career Award for Medical Scientists (2019)
- MSKCC Award for Teaching Excellence (2019)
- NCI K08 Mentored Career Development Award (2020)
- SARS-CoV-2 Research Project Award, Pershing Square Cohn Cancer Research Alliance (2020)
- Josie Robertson Investigator (2021-2026)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Santosha Vardhana discloses the following relationships and financial interests:
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