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The Robert Benezra Lab: Publications

Visit PubMed for a full listing of Robert Benezra’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L. & Weintraub, H. (1990). The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61(1):49-59.

Jen, Y., Weintraub, H. & Benezra, R. (1992). Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev 6(8):1466-79.

Pesce, S. & Benezra, R. (1993). The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity. Mol Cell Biol 13(12):7874-80.

Tournay, O. & Benezra, R. (1996). Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Mol Cell Biol 16(5):2418-30.

Li ,Y. & Benezra, R. (1996). Identification of a human mitotic checkpoint gene: hsMAD2. Science 274(5285):246-8.

Jen, Y., Manova, K. & Benezra, R. (1996). Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis. Dev Dyn 207(3):235-52.

Wassmann, K. & Benezra, R. (1998). Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Proc Natl Acad Sci USA 95(19):11193-8.

Lyden, D., Young, A.Z., Zagzag, D., Yan, W., Gerald, W., O’Reilly, R., Bader, B.L., Hynes, R.O., Zhuang, Y., Manova, K. & Benezra, R. (1999). Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401(6754):670-7.

Dobles, M., Liberal, V., Scott, M.L., Benezra, R. & Sorger, P.K. (2000). Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101(6):635-45.

Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., Wu, Y., Hicklin, D., Zhu, Z., Hackett, N.R., Crystal, R.G., Moore, M.A., Hajjar, K.A., Manova, K., Benezra, R.* & Rafii, S.* (2001). Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7(11):1194-201. *Co-corresponding authors.

Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S.W. & Benezra, R. (2007). Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11(1):9-23.

 Gupta, G.P., Perk, J., Acharyya, S., de Candia, P., Mittal, V., Todorova-Manova, K., Gerald, W.L., Brogi, E., Benezra, R.* & Massague, J.* (2007). ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc        Natl Acad Sci USA 104(49):19506-11. *Co-corresponding authors

Ciarrocchi, A., Jankovic, V., Shaked, Y., Nolan, D.J., Mittal, V., Kerbel, R., Nimer, S. & Benezra, R. (2007). Id1 restrains p21 expression to control endothelial progenitor cell formation. PLoS One 2(12):e1338.

Henke, E., Perk, J., Vider, J., de Candia, P., Chin, Y., Solit, D.B., Ponomarev, L., Cartegni, K., Manova, N., Rosen, N. & Benezra, R. (2008). Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo. Nat Biotechnol 26(1):91-100.

Nam, H.S. & Benezra, R. (2009). High levels of Id1 expression define B1 type adult neural stem cells. Cell Stem Cell 5(5):515-26.

Schvartzman, J.M.*, Sotillo, R.* & Benezra, R. (2010). Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer 10(2):102-15. *Both authors contributed equally

Sotillo, R., Schvartzman, J.M., Socci, N.D., & Benezra, R. (2010). Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464(7287):436-40.

Schvartzman, J.M., Duijf, P.H., Sotillo, R., Coker, C., & Benezra, R. (2011). Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell 19(6):701-14.

Granot, Z., Henke, E., Comen, E., King, T., Norton, L., & Benezra, R. (2011). Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20(3):300-14.

Duijf, P.H., Schultz, N., & Benezra, R. (2013). Cancer cells preferentially lose small chromosomes. Int J Cancer 132(10):2316-26.

Stankic, M., Pavlovic, S., Chin, Y., Brogi, E., Padua, D., Norton, L., Massague, J., & Benezra, R. (2013). TGF-β-Id1 signaling opposes Twist1 andI promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Rep 5(5):1228-42.

Lasorella, A., Benezra, R., & Iavarone, A. (2014). The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer 14(2):77-91

Zhang, N., Yantiss, R., Nam, H.S., Chin, Y., Zhou, X., Scherl, E., Bosworth, B., Subbaramaiah, K., Dannenberg, A.*, & Benezra, R.* (2014). ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury. Stem Cell Reports 3(5):716-24. *Co-corresponding authors

Cook, P.J., Thomas, R., Kinglsey, P.J., Fumiko, S., Montrose, D.C., Marnett, L.J., Tabar, V.S., Dannenberg, A.J.*, & Benezra, R.* (2016). Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma. Neuro-Oncology 18(10):1379-89. PMC5035519. *Co-corresponding authors.

Marks, D.H.*, Thomas, R.*, Shah, R., Khoo, C., Benezra, R. (2017). Mad2 overexpression uncovers a critical role for TRIP13 in mitotic exit. Cell Reports, 19:1832-1845. *Co-first authors

Cook, P. J., Thomas, R., Kannan, R., Sanchez de Leon, E., Drillon, A., Rosenblum, M. K., Scaltriti, M., Benezra, R.*, and Ventura, A.* (2017). Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target. Nat Comm, 8:15987 . *Co-corresponding authors