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The Morgan Huse Lab: Publications

Visit PubMed for a full listing of Morgan Huse’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Cheng, M., Santich, B., Xu, H., Ahmed, M., Huse, M., and Cheung, N. V. (2016). Successful Engineering of a Highly Potent Single-Chain-Variable-Fragment (scFv) Bispecific Antibody to Target Disialoganglioside (GD2) Positive Tumors. Oncoimmunology 5, e1168557.

Basu, R., Whitlock, B. M., Husson, J., Le Floc’h, A., Jin, W., Oyler-Yaniv, A., Dotiwala, F., Giannone, G., Hivroz, C., Biais, N., Lieberman, J., Kam, L. C., and Huse, M. (2016). Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell 165, 100-110.

Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. R., and Li, M. O. (2016). Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell 164, 365-377.

Nguyen Duc, T., and Huse, M. (2015). A Generalizable Platform for the Photoactivation of Cell Surface Receptors. ACS Chem. Bio. 10, 2435-2440.

Liu, X., and Huse, M. (2015). Immunological Synapse Formation: Cell Polarity During T cell-APC Interaction. In Klaus Ebnet (Ed.), Cell Polarity 1: Biological Role and Basic Mechanisms (pp. 247-275). Switzerland: Springer.

Xu, H., Cheng, M., Guo, H., Chen, Y., Huse, M., and Cheung, N. V. (2015). Retargeting T cells to GD2 pentasaccharide on human tumors using bispecific humanized antibody. Cancer Immunol. Res. 3, 266-277.

Le Floc’h, A., and Huse, M. (2015). Molecular Mechanisms and Functional Implications of Polarized Actin Remodeling at the T cell Immunological Synapse. Cell Mol. Life Sci. 72, 537-556.

Huse, M. (2014). Lipid-based Patterning of the Immunological Synapse. Biochem. Soc. Trans. 42, 1506-1511.

Chauveau, A., Le Floc’h, A., Bantilan, N. S., Koretzky, G. A., and Huse, M. (2014). Diacylglycerol Kinase a Establishes T Cell Polarity by Shaping Diacylglycerol Accumulation at the Immunological Synapse. Sci. Signal. 7, ra82.

Basu, R., Chen, Y., Quann, E. J., and Huse, M. (2014). The Variable Hinge Region of Novel PKCs Determines Localization to Distinct Regions of the Immunological Synapse. PLoS One 9, e95531.

Bashour, K. T., Gondarenko, A., Chen, H., Shen, K., Liu, X., Huse, M., Hone, J. C., and Kam, L. C. (2014). CD28 and CD3 Have Complementary Roles in T-cell Traction Forces. Proc. Nat. Acad. Sci. USA 111, 2241-2246.

Abeyweera, T. P., Kaissar, M., and Huse, M. (2013). Inhibitory Receptor Signaling Destabilizes Immunological Synapse Formation in Primary NK Cells. Front. Immunol. 4, 410.

Le Floc’h, A. Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y., and Huse, M. (2013). Annular PIP3 Accumulation Controls Actin Architecture and Modulates Cytotoxicity at the Immunological Synapse. J. Exp. Med. 210, 2721-2737.

Huse, M., Le Floc’h, A., and Liu, X. (2013). From Lipid Second-Messengers to Molecular Motors: Microtubule-Organizing Center Reorientation in T Cells. Immunol. Rev. 256, 95-106. 

Liu, X., Kapoor, T. M., Chen, J. K., and Huse, M. (2013). Diacylglycerol Promotes Centrosome Polarization in T Cells via Reciprocal Localization of Dynein and Myosin II. Proc. Nat. Acad. Sci. USA 110, 11976-11981. 

Gasteiger, G., Hemmers, S., Firth, M. A., Le Floc’h, A., Huse, M., Sun, J. C., and Rudensky, A. Y. (2013). IL-2-dependent Tuning of NK Cell Sensitivity for Target Cells is Controlled by Regulatory T Cells. J. Exp. Med. 210, 1167-1178. 

Pittari G., Liu X. R., Selvakumar A., Zhao Z., Merino E., Huse M., Chewning J. H., Hsu K. C., and Dupont B. (2013). NK Cell Tolerance of Self-Specific Activating Receptor KIR2DS1 in Individuals with Cognate HLA-C2 Ligand. J. Immunol. 190, 4650-4660. 

Huse, M., Milanoski, S. C., and Abeyweera, T. P. (2013). Building Tolerance by Dismantling Synapses: Inhibitory Receptor Signaling in Natural Killer Cells.  Immunol. Rev. 251, 143-153. 

Ouyang, W., Liao, W., Luo, C.T., Yin, N., Huse, M., Kim, M.V., Peng, M., Chan, P., Ma, Q., Mo, Y., Meijer, D., Zhao, K., Rudensky, A.Y., Atwal, G., Zhang, M.Q., and Li, M.O. (2012). Novel Foxo1-dependent Transcriptional Programs Control T(reg) Cell Function. Nature, 491, 554-559.

Merino, E., Abeyweera, T. P., Firth, M. A., Zawislak, C. L., Basu, R., Liu, X., Sun, J. C., and Huse, M. (2012). Protein Kinase C-q Clustering at Immunological Synapses Amplifies Effector Responses in Natural Killer Cells. J. Immunol. 189, 4859-4869.

Huse, M. (2012). Microtubule-Organizing Center Polarity and the Immunological Synapse: Protein Kinase C and Beyond.  Front. Immunol. 3, 235.

Quann, E. J., Liu, X., Altan-Bonnet, G., and Huse, M. (2011). A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells. Nat. Immunol. 12, 647-654

Huse, M. (2011). Lymphocyte Polarity, the Immunological Synapse and the Scope of Biological Analogy.  Bioarchitecture 1, 180-185.

Abeyweera, T. P., Merino, E., and Huse, M. (2011) Inhibitory Signaling Blocks Activating Receptor Clustering and Induces Cytoskeletal Retraction in Natural Killer Cells. J. Cell Biol. 192, 675-690.

Huse, M. (2010). Photochemical Approaches to T-cell Activation. Immunol. 130, 151-157.

Kuhns, M. S., Girvin, A. T., Klein, L. O., Chen, R., Jensen, K. D. C., Newell, E. W., Huppa, J. B., Lillemeier, B. F., Huse, M., Chien, Y., Garcia, K. C., and Davis, M. M. (2010). Evidence for a Functional Sidedness to the alphabetaTCR. Proc. Nat. Acad. Sci. USA 107, 5094-5099.

Quann, E. J., Merino, E., Furuta, T., and Huse, M. (2009). Localized Diacylglycerol Drives the Polarization of the Microtubule-Organizing Center in T cells. Nat. Immunol. 10, 627-635.

Huse, M. (2009). The T-cell-receptor Signaling Network. J. Cell. Sci. 122, 1269-1273.

Huse, M., Quann, E. J., and Davis, M. M. (2008). Shouts, Whispers, and the Kiss of Death: Directional Secretion in T cells. Nat. Immunol. 9, 1105-1111.

Huse, M.*, Klein, L. O.*, Girvin, A. T., Faraj, J. M., Li, Q., Kuhns, M. S., and Davis, M. M. (2007). Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photocaged Agonist. Immunity, 27, 76-88 *equal contribution

Davis, M. M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B. F., and Li, Q.-J. (2007). T Cells as a Self-Referential, Sensory Organ. Annu. Rev. Immunol. 25, 681-695

Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S., and Davis, M. M. (2006). T Cells Use Two Directionally Distinct Pathways for Cytokine Secretion. Nat. Immunol. 7, 247-255.

Krogsgaard, M., Li, Q.-J., Sumen, C., Huppa, J. B., Huse, M., and Davis, M. M. (2005). Agonist/Self Peptide-MHC Heterodimers Drive T Cell Activation and Sensitivity. Nature 434, 238-243

Ottesen J. J., Huse, M., Sekedat, M. D., and Muir, T. W. (2004). Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference for the Activated TbetaR-I Kinase. Biochemistry 43, 5698-5706.

Huse, M. and Kuriyan, J. (2002). The Conformational Plasticity of Protein Kinases. Cell 109, 275-282.

Huse, M. (2002). Structural Biology: Alive and Skiing. Structure 10, 137-138.

Flavell, R. R., Huse, M., Goger, M., Trester-Zedlitz, M., Kuriyan, J., and Muir, T. W. (2002). Efficient Semi-synthesis of a Tetraphosphorylated Analog of the Type I TGF-beta Receptor. Org. Lett.4,165-168.

Wu, J.-W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D. J., Kyin, S., Muir, T. W., Fairman, R., Massagué, J., and Shi, Y. (2001). Crystal Structure of Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF-beta Signaling. Mol. Cell 8, 1277-1289.

Huse, M., Muir, T. W., Xu, L., Chen, Y.-G., Kuriyan, J., and Massagué, J. (2001). The TGF-beta Receptor Activation Process: An Inhibitor- to Substrate-binding Switch. Mol. Cell 8, 671-682.

Huse, M., Holford, M. N., Kuriyan J., and Muir, T. W. (2000). Semi-synthesis of Hyperphosphorylated Type I TGF-beta Receptor: Addressing the Mechanism of Kinase Activation. J. Am. Chem Soc. 122, 8337-8338

Huse, M., Chen, Y. G., Massagué, J., and Kuriyan, J. (1999). Crystal Structure of the Cytoplasmic Domain of the Type I TGF-beta Receptor in Complex with FKBP12. Cell 96, 425-436.

Huse, M., Eck, M. J., and Harrison, S. C. (1998). A Zn2+ Ion Links the Cytoplasmic Tail of CD4 to the N-terminal region of Lck. J. Biol. Chem. 273, 18729-18733.

Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., and Miller, W. T. (1997). Activation of the Src-family Tyrosine Kinase Hck by SH3 Domain Displacement. Nature 385, 650-653.