My laboratory research focuses on defining the genetic aberrations that characterize bladder cancer, thereby identifying mutations that may serve as targets for novel therapies in this disease. Specifically, alterations within the PI3 kinase/Akt/mTOR pathway are commonly found in bladder cancer, and efforts are under way to understand the biologic effects of pharmacologic inhibition of this pathway. Loss of the TSC1 protein, a negative regulator of mTOR activation, has been shown to contribute to dramatic sensitivity of bladder tumors to everolimus therapy. We are currently elucidating the mechanisms underpinning drug sensitivity and are defining the pattern of co-alterations with TSC1 loss in bladder cancer using next-generation sequencing techniques.
Disclosures
Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.
MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.
Gopa Iyer discloses the following relationships and financial interests:
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Aadi Bioscience, Inc.
Professional Services and Activities -
BicycleTX Limited
Professional Services and Activities -
Carden Jennings Publishing
Professional Services and Activities -
Curio Science LLC
Professional Services and Activities
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Dava Oncology
Professional Services and Activities (Uncompensated) -
EMD Serono, Inc
Professional Services and Activities -
Flare Therapeutics
Professional Services and Activities (Uncompensated) -
Loxo Oncology
Professional Services and Activities (Uncompensated)
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This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.
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