More Information: Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

The Lydia Finley Lab: Publications

German N.J., Yoon H., Yusuf R.Z., Murphy J.P., Finley L.W., Laurent G., Haas W., Satterstrom F.K., Guarnerio J., Zaganjor E., Santos D., Pandolfi P.P., Beck A.H., Gygi S.P., Scadden D.T., Kaelin W.G. Jr, Haigis M.C. (2016). PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 63, 1006-1020.

Intlekofer, A.M., Dematteo, R.G., Venneti, S., Finley, L.W., Lu, C., Judkins, A.R., Rustenburg, A.S., Grinaway, P.B., Chodera, J.D., Cross, J.R., and Thompson, C.B. (2015). Hypoxia induces production of L-2-hydroxyglutarate. Cell Metab. 22, 304-311.       

Carey, B.W.*, Finley, L.W.* (equal contribution), Cross, J.R., Allis, C.D., and Thompson, C.B. (2015). Intracellular -ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 518, 413-416.     

Ye, J., Fan, J., Venneti, S., Wan, Y.W., Pawel, B.R., Zhang, J., Finley, L.W., Lu, C., Lindsten, T., Cross, J.R., Qing, G., Liu, Z., Simon, M.C., Rabinowitz, J.D., and Thompson, C.B. (2014). Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4, 1406-1417.

Jeong, S.M., Lee, J., Finley, L.W., Schmidt, P.J., Fleming, M.D., and Haigis, M.C. (2015). SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 34, 2115-2124.

Finley, L.W. and Thompson, C.B. The Metabolism of Cell Growth and Proliferation. The Molecular Basis of Cancer: Fourth Edition. (2014). Mendelsohn, Howley, Israel, Gray and Thompson Editors. Elsevier, Saunders. Chapter 13: 191-208.

Laurent, G., de Boer, V.C., Finley, L.W., Sweeney, M., Lu, H., Schug, T.T., Cen, Y., Jeong, S.M., Li, X., Suave, A.A., and Haigis, M.C. (2013). SIRT4 represses peroxisome proliferator-activated receptor  activity to suppress hepatic fat oxidation. Mol Cell Biol. 33, 4552-4561.

Jeong, S.M., Xiao, C., Finley, L.W., Lahusen, T., Souza, A.L., Pierce, K., Li, Y.H., Wang, X., Laurent, G., German, N.J., Xu, X., Li, C., Wang, R.H., Lee, J., Csibi, A., Cerione, R., Blenis, J., Clish, C.B., Kimmelman, A., Deng, C.X., and Haigis, M.C. (2013). SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 23, 450-463.

Lee, P.C., Dodart, J.C., Aron, L., Finley, L.W., Bronson, R.T., Haigis, M.C., Yankner, B.A., and Harper, W. (2013). Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 50, 172-184.

Finley, L.W., Zhang, J., Ye, J., Ward, P.S., and Thompson, C.B. (2013). SnapShot: Cancer Metabolism Pathways. Cell Metab. 17, 466.

Peserico, A., Chiacchiera, F., Grossi, V., Matrone, A., Latorre, D., Simonatto, M., Fusella, A., Ryall, J., Finley, L.W., Haigis, M.C., Villani, G., Puri, P.L., Sartorelli, V., and Simone, C. (2013). A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 70, 2015-2029.

Carracedo, A., Weiss, D., Leliaert, A.K., Bhasin, M., De Boer, V., Laurent, G., Adams, A., Song, S.J., Ito, K., Finley, L., Libermann, T., Gerhart-Hines, Z., Puigserver, P., Haigis, M.C., Maratos-Flier, E., Richardson, A.L., Schafer, Z.T., and Pandolfi, P.P. (2012). A metabolic pro-survival role for PML in breast cancer. J Clin Invest. 122, 3088-3100.

Inuzuka, H., Gao, D., Finley, L.W., Shaik, S., Wan, L., Chin, Y.R., Zhai, B., Fukushima, H., Lau, A.W., Gygi, S.P., Nakayama, K., Haigis, M.C., Toker, A., and Wei, W. (2012). Acetylation-dependent regulation of Skp2 function. Cell. 150, 179-193.

Finley, L.W., and Haigis, M.C. (2012). Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med. 18, 516-523.

Haigis, M.C., Deng, C.X., Finley, L.W., Kim, H.S., Guis, D. (2012). SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res. 72, 2468-2472.

Massimiliano, C., Jang, Y.C., Finley, L.W., Haigis, M., and Wagers, A. (2012). Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 10, 515-519.

Finley, L.W., Lee, J., Souza, A.L., Desquiret-Dumas, V., Bullock, K., Rowe, G.C., Procaccio, V., Clish, C.B., Arany, Z., and Haigis, M.C. (2012). Skeletal muscle transcriptional coactivator PGC-1 mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci USA. 109, 2931-2936.

Finley, L.W., Haas, W., Desquiret-Dumas, V., Wallace, D.C., Procaccio, V., Gygi, S.P., and Haigis, M.C. (2011). Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One. 6, e23295.

Finley, L.W., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P.I., Cardoso, S.M., Clish, C.B., Pandolfi, P.P., and Haigis, M.C. (2011). SIRT3 opposes reprogramming of cancer cell metabolism through HIF1 destabilization. Cancer Cell. 19, 416-428.

Verdin E., Hirschey M.D., Finley L.W., and Haigis M.C. (2010). Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. 35, 669-675.

Finley, L.W., and Haigis, M.C. (2009). The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev. 8, 173-188.