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The Lydia Finley Lab: Publications

View a full listing of Lydia Finley’s journal articles.


Selected Publications

Finley, L.W.*, Vardhana, S.A.*, Carey, B.W.*, Alonso-Curbelo, D., Koche, R., Chen, Y., Wen, D., King, B., Radler, M.R., Rafii, S., Lowe, S.W., Allis, C.D., and Thompson, C.B. Pluripotency transcription factors and Tet1/2 enable Brd4-independent maintenance of stem cell identity. In Press, Nature Cell Biology. (*, equal contribution)

Zahalka, A.H., Arnal-Estape, A., Maryanovich, M., Nakahara, F., Cruz, C.D., Finley, L.W.S., and Frenette, P.S. (2017). Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science 358, 321-326.

German N.J., Yoon H., Yusuf R.Z., Murphy J.P., Finley L.W., Laurent G., Haas W., Satterstrom F.K., Guarnerio J., Zaganjor E., Santos D., Pandolfi P.P., Beck A.H., Gygi S.P., Scadden D.T., Kaelin W.G. Jr, Haigis M.C. (2016). PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 63, 1006-1020.

Intlekofer, A.M., Dematteo, R.G., Venneti, S., Finley, L.W., Lu, C., Judkins, A.R., Rustenburg, A.S., Grinaway, P.B., Chodera, J.D., Cross, J.R., and Thompson, C.B. (2015). Hypoxia induces production of L-2-hydroxyglutarate. Cell Metab. 22, 304-311. 

Carey, B.W.*, Finley, L.W.* (equal contribution), Cross, J.R., Allis, C.D., and Thompson, C.B. (2015). Intracellular -ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 518, 413-416.     

Ye, J., Fan, J., Venneti, S., Wan, Y.W., Pawel, B.R., Zhang, J., Finley, L.W., Lu, C., Lindsten, T., Cross, J.R., Qing, G., Liu, Z., Simon, M.C., Rabinowitz, J.D., and Thompson, C.B. (2014). Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4, 1406-1417.

Laurent, G., de Boer, V.C., Finley, L.W., Sweeney, M., Lu, H., Schug, T.T., Cen, Y., Jeong, S.M., Li, X., Suave, A.A., and Haigis, M.C. (2013). SIRT4 represses peroxisome proliferator-activated receptor  activity to suppress hepatic fat oxidation. Mol Cell Biol. 33, 4552-4561.

Jeong, S.M., Xiao, C., Finley, L.W., Lahusen, T., Souza, A.L., Pierce, K., Li, Y.H., Wang, X., Laurent, G., German, N.J., Xu, X., Li, C., Wang, R.H., Lee, J., Csibi, A., Cerione, R., Blenis, J., Clish, C.B., Kimmelman, A., Deng, C.X., and Haigis, M.C. (2013). SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 23, 450-463.