Lydia Finley: Publications

Lydia Finley: Publications



α-Ketoglutarate links p53 to cell fate during tumour suppression.
Morris JP 4th*, Yashinskie JJ*, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS#, Lowe SW#. Nature. 2019 Sep;573(7775):595-599. doi: 10.1038/s41586-019-1577-5. Epub 2019 Sep 18. PMID: 31534224. (*co-first, #co-corresponding)

Glutamine independence is a selectable feature of pluripotent stem cells.
Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Nat Metab. 2019 Jul;1(7):676-687. doi: 10.1038/s42255-019-0082-3. Epub 2019 Jul 8. PMID: 31511848

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.
Finley LWS*, Vardhana SA*, Carey BW*, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB. Nat Cell Biol. 2018 May;20(5):565-574. doi: 10.1038/s41556-018-0086-3. Epub 2018 Apr 16. PMID: 29662175 (* equal contribution)

Adrenergic nerves activate an angio-metabolic switch in prostate cancer.
Zahalka AH, Arnal-Estapé A, Maryanovich M, Nakahara F, Cruz CD, Finley LWS, Frenette PS. Science. 2017 Oct 20;358(6361):321-326. doi: 10.1126/science.aah5072. PMID: 29051371

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC. Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014. PMID: 27635760

Hypoxia Induces Production of L-2-Hydroxyglutarate.
Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB. Cell Metab. 2015 Aug 4;22(2):304-11. doi: 10.1016/j.cmet.2015.06.023. Epub 2015 Jul 23. PMID: 26212717

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells.
Carey BW*, Finley LW*, Cross JR, Allis CD, Thompson CB. Nature. 2015 Feb 19;518(7539):413-6. doi: 10.1038/nature13981. Epub 2014 Dec 10. PMID: 25487152. (*equal contribution)    

Serine catabolism regulates mitochondrial redox control during hypoxia.
Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB. Cancer Discov. 2014 Dec;4(12):1406-17. doi: 10.1158/2159-8290.CD-14-0250. Epub 2014 Sep 3. PMID: 25186948

Review Articles

Metabolic signatures of cancer cells and stem cells.
Intlekofer AM, Finley LWS. Nat Metab. 2019 Feb;1(2):177-188. doi: 10.1038/s42255-019-0032-0. Epub 2019 Feb 11. PMID: 31245788

Metabolic regulation of chromatin modifications and gene expression.
Schvartzman JM, Thompson CB, Finley LWS. J Cell Biol. 2018 Jul 2;217(7):2247-2259. doi: 10.1083/jcb.201803061. Epub 2018 May 14. Review. PMID: 29760106