Kayvan R. Keshari: Publications

Schild T, Wallisch P, Zhao Y, Wang YT, Haughton L, Chirayil R, Pierpont K, Chen K, Nunes-Violante S, Cross J, de Stanchina E, Thompson CB, Scheinberg DA, Perry JSA, Keshari KR. (2025) Metabolic engineering to facilitate anti-tumor immunity Cancer Cell. Mar 10;43(3):552-562.e9. doi: 10.1016/j.ccell.2025.02.004.

Patel S, Porcari P, Coffee E, Kim N, Berishaj M, Peyear T, Zhang G, Keshari KR. (2024) Simultaneous noninvasive quantification of redox and downstream glycolytic fluxes reveals compartmentalized brain metabolism. Science Advances Dec 20;10(51):eadr2058. doi: 10.1126/sciadv.adr2058.

Marin-Valencia I, Kocabas A, Rodriguez-Navas C, Miloushev VZ, González-Rodríguez M, Lees H, Henry KE, Vaynshteyn J, Longo V, Deh K, Eskandari R, Mamakhanyan A, Berishaj M, Keshari KR. (2024) Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency Cell Metabolism Jun 4;36(6):1394-1410.e12. doi: 10.1016/j.cmet.2024.05.002

Keshari KR, Heller DA, Boltyanskiy R, Hricak H, Magaldi T, Overholtzer M. Engineering focusing on cancer. (2024) Cancer Cell Jul 8;42(7):1138-1141. doi: 10.1016/j.ccell.2024.04.013.

Pigliapochi R, Peyear T, Ruan T, Keshari KR. (2024) Hyperpolarized Nano-NMR Platform for Quantification of Mass Limited Samples. Analytical Chemistry. Jul 22:10.1021/acs.analchem.4c02378. doi: 10.1021/acs.analchem.4c02378

Zhang G, Deh K, Park H, Cunningham CH, Bragagnolo ND, Lyashchenko S, Ahmmed S, Leftin A, Coffee E, Kelsen D, Hricak H, Miloushev V, Mayerhoefer M, Keshari KR. (2024) Assessment of the Feasibility of Hyperpolarized [1-¹³C]pyruvate Whole-Abdomen MRI using D₂O Solvation in Humans. J Magn Reson Imaging Dec;60(6):2747-2749. doi: 10.1002/jmri.29322

DeBerardinis, R. J., & Keshari, K. R. (2022). Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell, 185(15), 2678–2689. https://doi.org/10.1016/j.cell.2022.06.029

Tee, S. S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R. M., Chirayil, R., Jeong, S., Shakiba, M., Kastenhuber, E. R., Chen, S., Sigel, C., Lowe, S. W., Jarnagin, W. R., Thompson, C. B., Schietinger, A., & Keshari, K. R. (2022). Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances, 8(14), eabm7985. https://doi.org/10.1126/sciadv.abm7985

Jeong, S., Savino, A. M., Chirayil, R., Barin, E., Cheng, Y., Park, S. M., Schurer, A., Mullarky, E., Cantley, L. C., Kharas, M. G., & Keshari, K. R. (2021). High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. Cell metabolism, 33(1), 145–159.e6. https://doi.org/10.1016/j.cmet.2020.12.005

Granlund, K. L., Tee, S. S., Vargas, H. A., Lyashchenko, S. K., Reznik, E., Fine, S., Laudone, V., Eastham, J. A., Touijer, K. A., Reuter, V. E., Gonen, M., Sosa, R. E., Nicholson, D., Guo, Y. W., Chen, A. P., Tropp, J., Robb, F., Hricak, H., & Keshari, K. R. (2020). Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell metabolism, 31(1), 105–114.e3. https://doi.org/10.1016/j.cmet.2019.08.024

Salamanca-Cardona, L., Shah, H., Poot, A. J., Correa, F. M., Di Gialleonardo, V., Lui, H., Miloushev, V. Z., Granlund, K. L., Tee, S. S., Cross, J. R., Thompson, C. B., & Keshari, K. R. (2017). In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell metabolism, 26(6), 830–841.e3. https://doi.org/10.1016/j.cmet.2017.10.001

Jeong, S., Eskandari, R., Park, S. M., Alvarez, J., Tee, S. S., Weissleder, R., Kharas, M. G., Lee, H., & Keshari, K. R. (2017). Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Science advances, 3(6), e1700341. https://doi.org/10.1126/sciadv.1700341