Molecular Pharmacology Program

The Karuna Ganesh Lab

Share
Print

Research

Karuna Ganesh
Karuna Ganesh, MD, PhD
Medical Oncologist

Assistant Professor

Metastasis causes >90% of cancer death.  The emergence, persistence, therapy resistance and lethality of metastatic cancer is driven by dynamic and tenacious metastasis stem cells (MetScs). The Ganesh lab focuses on understanding the molecular mechanisms that underlie the emergence of regenerative plasticity during metastasis.  We employ cutting edge patient-derived organoid and mouse models of colorectal cancer, transcriptomic, epigenomic and single cell approaches, and mechanistic studies to: (1) elucidate how tumor invasion and dissemination induce phenotypic plasticity enabling the emergence of pro-metastatic regenerative traits (2) dissect the role of stromal cells, including immune cells, in promoting and constraining MetSC plasticity (3) define key signaling nodes that drive MetSC plasticity and develop therapeutic strategies for targeting such vulnerabilities and (4) collaborate with clinicians to understand mechanisms of therapy resistance in metastasis.

The Karuna Ganesh Lab

Publications

Ganesh K, Basnet H, Laughney AM, Kaygusuz Y, He L, O’Rourke KP, Reuter V, Huang YH, Er EE, Masilionis I, Weiser MR, Saltz LB, Garcia-Aguilar J, Koche R, Lowe SW, Pe’er D, Shia J, Massagué J. L1CAM marks the regenerative origin of metastasis stem cells in colorectal cancer. Nature Cancer1, 28–45 (2020). https://doi.org/10.1038/s43018-019-0006-x

View All Publications

People

Karuna Ganesh

Karuna Ganesh, MD, PhD

Medical Oncologist

Assistant Professor

  • Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.
  • MD, PhD, University of Cambridge (UK)
ganeshk@mskcc.org
Email Address
View physician profile
Physician profile

Members

Simran Asawa
Simran Asawa

Senior Research Technician

Francesco Cambuli
Francesco Cambuli

Research Fellow

Saskia Hartner
Saskia Hartner

Graduate Research Assistant

Mel-Quann Hodge
Mel-Quann Hodge

Lab Assistant

Qingwen Jiang
Qingwen Jiang

Research fellow

Ahmed Mahmoud
Ahmed Mahmoud
Valeria Sgambati

Post Doc

Lab Alumni
Tamiika White
Tamiika White

Lab Assistant

Lab Affilations

Achievements

  • Damon Runyon Clinical Investigator Award (2019)
  • Burroughs Wellcome Career Award for Medical Scientists (2019)
  • Josie Robertson Investigator (2019)
  • NIH/NCI K08 Clinician Scientist Career Development Award (2018)
  • Investigator, Stand Up to Cancer Colorectal Cancer Dream Team (2017)
Read more
  • American Cancer Society Postdoctoral Fellowship (2017)
  • Shulamit Katzman Endowed Postdoctoral Fellowship (2017)
  • Conquer Cancer Foundation of ASCO Young Investigator Award (2016)
  • AACR Basic Cancer Research Fellowship (2016)
  • MRC-LMB PhD Scholarship (2006)
  • Gates Cambridge Scholarship (2004)

Lab News & Events

Open Positions

Career Opportunities

Postdoctoral Positions Fully funded postdoctoral positions are currently available for highly motivated candidates with a background in cancer biology, epigenetics, tumor immunology, epithelial stem cell biology or molecular biology.

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Karuna Ganesh discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


View all disclosures