John Petrini: Publications

John Petrini: Publications

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  1. Kim, JH., Penson, A.V., Taylor,B.S., Petrini, J.H., (2019) Nbn-Mre11 interaction is required for tumor suppression and genomic integrity. 2019:201905305. doi: 10.1073/pnas. 1905305116. Proc Natl Acad Sci. PMC6660787
  2. Kim, JH., Grosbart, M., Anand, R., Wyman C., Cejka, P., Petrini, J.H., (2017) The Mre11-Nbs1 interface is essential for viability and tumor suppression. Cell Rep. 18. (2) 496-507 PMC5234850
  3. Henssen, A. G., Reed, C., Jiang, E., Garcia, H.D., von Stebut, J., MacArthur, I.C., Hundsdoerfer, P., Kim, J.H., de Stanchina, E., Kuwahara, Y., Hosoi, H., Ganem, N., Dela Cruz, F., Kung, A. L., Schulte, J.H.,  Petrini J.H., Kentsis, A. (2017) Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid Tumors. Science Transl Med. 9 (414) DOI: 10.1126/scitranslmed.aam9078 PMC5683417
  4. Park YB, Hohl, M., Padjasek, M., Jeong, E., Kyeong J.S., Kretzel, A., Petrini, J.H., Cho, Y., (2016) Eukaryotic Rad50 Functions as a Rod-shaped Dimer. Nat Struct Mol Biol (3) 248-257 PMC5625350
  5. Hohl, M., Kochanczyk, T., Tous, C., Aguilera, A., Krezel, A. Petrini, J.H. (2015) Interdependence of the Rad50 hook and globular domain functions. Mol. Cell. 57: 479-491. PMC4527088
  6. Al-Ahmadie, H., Iyer, G., Hohl, M., Inagaki, A., Shultz N., Hanrahan, AJ., Scott, S.N., Brannon, A.R., McDermott, G.C., Pirun, M., Ostrovnaya, I., Kim, P., Socci, N.D., Viale, A., Schwartz, G.K., Reuter, V., Bochner, B.H., Rosenberg, JE., Bajorin, DF., Berger, M.F., Petrini, J.H.J., Solit, D.B., Taylor, B.S. (2014) Synthetic lethality in ATM-deficient RAD50-mutant tumors underlie outlier response to cancer therapy.  Cancer Discov. 9. 1014-1021 PMC4155059
  7. Roset, R., Inagaki, A., Hohl, M., Brenet, F., Lafrance-Vanasse, J., Lange, J., Scandura, J., Tainer, J., Keeney, S., Petrini, J.H. (2014) The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev, 28. 451-462 PMC3950343
  8. Gupta, G., Vanness, K., Barlas, A., Manova-Todorova, K., Wen, Y.H., Petrini, J.H. (2013) The Mre11 Complex Suppresses Oncogene-driven Breast Tumorigenisis and Metastasis. Mol Cell 52. 353-365 PMC3902959
  9. Ballew, B., Joseph, V., De, S., Sarek, G., Vannier, J-B., Stracker, T., Schrader, K.A., Small, T.N., O’Reilly, R., Manschreck, C., Harlan Fleischut, M.M., Sullivan, J., Stratton, K., Yeager, M., Jacobs, K., Giri, N., Alter, B.P., Boland, J., Burdett, L., Offit, K., Boulton, S., Savage, S.A., Petrini, J.H.J.  (2013) A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome. PLoS Genetics, 8.: e1003695 PMC3757051
  10. Balestrini, A., Ristic, D., Dionne, I., Liu, X., Wyman, C., Wellinger, R.C., Petrini, J.H. (2013) The Ku heterodimer and the metabolism of single-ended DNA double strand breaks. Cell Reports, 3. 2033-45. PMC3815622