Molecular Biology Program
The John Petrini Lab
Work in our laboratory is focused on understanding the molecular transactions that govern chromosome stability and replication. The association of cancer predisposition and other pathology with mutations that affect chromosomal metabolism forms the basis of our interest in this process. In this regard, we focus on a conserved multiprotein complex that includes Mre11, Rad50, and Nbs1 in mammals or Xrs2 in the budding yeast S. cerevisiae. Our laboratory has isolated and characterized the human Mre11 complex, hMre11, hRad50, and Nbs1. We proved that an analogue of the S. cerevisiae Mre11 complex exists in human cells, and subsequently established definitive evidence that the yeast and human complexes mediate double-strand break repair in S. cerevisiae and mammalian cells, respectively. Our data suggest that in human cells, the complex acts as a sensor of DNA damage that participates in the activation of cell cycle checkpoints following g-irradiation.
Kim, JH., Penson, A.V., Taylor,B.S., Petrini, J.H., (2019) Nbn-Mre11 interaction is required for tumor suppression and genomic integrity. 2019:201905305. doi: 10.1073/pnas. 1905305116. Proc Natl Acad Sci. PMC6660787
Kim, JH., Grosbart, M., Anand, R., Wyman C., Cejka, P., Petrini, J.H., (2017) The Mre11-Nbs1 interface is essential for viability and tumor suppression. Cell Rep. 18. (2) 496-507 PMC5234850
John Petrini, PhD
Chair, Molecular Biology Program, SKI; Director, The Functional Genomics Initiative
- Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.
- PhD, University of Michigan Medical School
The work in our lab is focused on the DNA damage response (DDR), a network of functions comprising DNA damage signaling, DNA repair, and DNA damage dependent cell cycle regulation.
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John Petrini discloses the following relationships and financial interests:
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