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Kim H., Rafiuddin-Shah M., Tu H.-C, Jeffers J., Zambetti G.P., Hsieh J. J.-D., Cheng E.H.-Y. Hierarchical Regulation of Mitochondrion-Dependent Apoptosis by BCL-2 subfamilies. Nature Cell Biology, 2006; 8:1348-1358.

Gavathiotis E., Suzuki M., Davis M.L., Pitter K., Bird G.H., Katz S.G., Tu H.C., Kim H., Cheng E.H.-Y., Tjandra N., Walensky L.D. BAX activation is initiated at a novel interaction site. Nature 2008; 455:1076-1081.

Tu H.-C., Ren D., Wang G., Chen D.Y., Westergard T.D., Kim H., Sasagawa S., Hsieh, J.J-D., Cheng E.H.-Y., The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci USA 2009; 106:1093-1098.

Ren D., Kim H., Tu H., Westergard T.D., Fisher J.K., Rubens J.A., Korsmeyer S.J., Hsieh J.J.-D., Cheng E.H.-Y. The VDAC2-BAK Rheostat Controls Thymocyte Survival. Science Signaling 2009; 2: ra48.

Kim H., Tu H., Ren D., Takeuchi O., Jeffers J.R., Zambetti G.P., Hsieh J.J.-D., Cheng E.H.-Y. Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis. Molecular Cell 2009; 36:487-499.

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Liu H., Westergard T.D., Cashen A., Piwnica-Worms D.R., Kunkle L., Vij R., Pham C.G., DiPersio J., Cheng E.H., Hsieh J.J. Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4. Cancer Cell 2014; 25: 530-42.

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Inoue-Yamauchi A., Jeng P.S., Kim K., Chen H.C., Han S., Ganesan Y.T., Ishizawa K., Jebiwott S., Dong Y., Pietanza M.C., Hellmann M.D., Kris M.G., Hsieh J.J., and Cheng E.H. Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy. Nature Communications 2017; 8: 16078.

Wang G., Tu H.C., Dong Y., Skanderup A.J., Wang Y., Takeda S., Ganesan Y.T., Han S., Liu H., Hsieh J.J., Cheng E.H. ΔNp63 inhibits oxidative stress-induced cell death including ferroptosis and cooperates with the BCL-2 family to promote clonogenic survival. Cell Reports 2017; 21: 2926–2939.

Tanaka K, Yu HA, Yang S, Han S, Selcuklu SD, Kim K, Ramani S, Ganesan YT, Moyer A, Sinha S, Xie Y, Ishizawa K, Osmanbeyoglu HU, Lyu Y, Roper N, Guha U, Rudin CM, Kris MG, Hsieh JJ, Cheng EH. Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis. Cancer Cell. 2021 Sep 13;39(9):1245-1261.e6. doi: 10.1016/j.ccell.2021.07.006. Epub 2021 Aug 12. PMCID: PMC8440494.

Xie Y, Sahin M, Sinha S, Wang Y, Nargund AM, Lyu Y, Han S, Dong Y, Hsieh JJ, Leslie CS, Cheng EH. SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes. Nat Cancer. 2022 Feb 3. doi: 10.1038/s43018-021-00316-3. Epub ahead of print.