Paucar Iza, Y, Tyler Park, Eliyambuya Baker, Gayathri Shibu, Tilman Hoelting, Greyson Feather, Anushka Yadav, Yollanda Parisotto, Zihan Zhao, Blossom Akagbosu, Marc Elosua Bayes, Logan Fisher, Lucas James, Jianping Ma, Benjamin Philpot, Behdad Afzali, Christiina Leslie, Brown C. (2026) Ontogeny and transcriptional regulation of Thetis cells. Nature doi: 10.1038/s41586-026-10198-z
Nguyen, A, Logan Fisher*, Jennifer Ahn, Michelle Zuo, Tyler Park, Anushka Yadav , Miki Gams, Kei Haniuda, Dragos Dasoveanu, Conglei Li, Lesley Ward, Angela Wang , Zakieh Tayyebi, Daria Trofimova, Trevor McKee, Cathy Mendelsohn, John Allingham, Cynthia Guidos, Blandine Maître, Jennifer L Gommerman†, Brown C. (2025) Sequential Lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate. Nature Immunology doi: 10.1038/s41590-025-02329-x
Hoelting T, Park T, Brown C. (2025) Antigen-presenting cells as arbiters of mucosal tolerance and immunity. Nature Immunology doi: 10.1038/s41590-025-02320-6
Cabric V†, Parisotto Y†, Park T, Akagbosu B, Zhao Z, Lo Y, Fisher L, Shibu G, Paucar Iza Y, Leslie C, Brown C. (2025). A wave of Thetis cells imparts tolerance to food early in life Science. 389,268-274 doi:10.1126/science.adp0535
Cabric V, Brown C. (2025) Thetis cells: regulators of intestinal immune tolerance. Current Opinions Immunology. https://doi.org/10.1016/j.coi.2025.102570
Remsik, J., Tong, X., Kunes, R. Z., Li, M. J., Estrera, R., Snyder, J., Thomson, C., Osman, A. M., Chabot, K., Sener, U. T., Wilcox, J. A., Isakov, D., Wang, H., Bale, T. A., Chaligné, R., Sun, J. C., Brown, C., Pe’er, D., & Boire, A. Interferon-γ orchestrates leptomeningeal anti-tumour response. Nature. 2025 https://doi.org/10.1038/s41586-025-09012-z
Paucar Iza Y, Brown C. (2024) Early life imprinting of intestinal tolerance and tissue homeostasis. Immunological Reviews 323:303-315
Brown C, Rudensky A. (2023) Spatiotemporal regulation of peripheral T cell tolerance. Science 380:472-478
Ramanan D, Pratama A, Zhu Y, Venezia O, Sassone-Corsi M, Chowdhary K, Galván-Peña S, Sefik E, Brown C, Gélineau A , Mathis D , Benoist C. (2023) Regulatory T cells in the face of the intestinal microbiota. Nature Reviews Immunology, 23:749-762
Park, T., Leslie, C., Rudensky, A., Brown, C. Reconciling the spectrum of RORgt+ antigen-presenting cells. bioRxiv. 2023. https://doi.org/10.1101/2023.11.01.565227
Persad S, Choo Z-N, Dien C, Sohail, N, Masilionis I, Chaligné R, Nawy T, Brown C, Sharma R, Pe’er I, Setty M, Pe’er D. SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data. Nature Biotech. 2023. DOI: 10.1038/s41587-023-01716-9
Cabric V, Brown C. (2023) Thymic mimicry: the art of imitation. J. Exp. Med. 220: e20231010
Akagbosu B,†, Tayyebi Z,†, Shibu G, Paucar Iza Y, Deep D, Parisotto Y, Fisher L, Pasolli HA, Thevin V, Elmentaite R, Knott M, Hemmers S, Jahn L, Friedrich C, Verter J, Wang Z-M, van den Brink M, Gasteiger G, Grünewald TGP, Marie JC, Leslie C, Rudensky AY*, Brown C*. Novel antigen-presenting cell imparts T-reg dependent tolerance to the gut microbiota. Nature. 2022. 610, 752–760 doi:10.1038/s41586-022-05309-5 *co-corresponding †equal contribution
Mendoza A, Yewdell W, Hoyos B, Schizas M, Bou-Puerto R, Michaels A, Brown C, Chaudhuri J, Rudensky A. (2021). Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity. Sci Immunol 6:4710.
Brown C, Gottschalk R. (2021) Volume control: turning the dial on regulatory T cells. Cell 184:3847-3849
Brown C, Rudensky A. (2021) Conceiving the inconceivable: the function of Aire in immune tolerance to peripheral tissue-restricted antigens in the thymus. J Immunol 206:245-247
Brown C, Wolchok J. (2020) PD-L1 Blockade Therapy: Location, Location, Location. Cancer Cell 38:615-617
Brown C, Rudensky A. (2020). Enforcing T cell innocence. Science 367:247-248
Thangavelu G, Wang C, Loschi M, Saha A, Osborn M, Furlan S, Aoyama K, Mcdonald-Hyman C, Aguilar E, Janesick A, Chandraratna R, Refaeli Y, Macdonald K, Hill G, Zeiser R, Maillard I, Serody J, Murphy W, Munn D, Blumberg B, Brown C, Kuchroo V, Kean L, Hippen K, Noelle R, Blazar B. (2020). Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses Blood 137:1090-1103
Penkava F, Velasco-Herrera M, Young M, Yager N, Nwosu L, Arthur Pratt, Alicia Lledo Lara, Charlotte Guzzo, Asher Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Brown C, Croxford A, Isaacs J Teichmann S, Bowness P, Behjati S, Al-Mossawi H. (2020). Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nature Communications 11:4767
Brown C,*† Gudjohnson H,* Pritykin Y, Deep D, Mendoza A, Leslie C, Pe’er D, Rudensky, A, (2019). Transcriptional basis of dendritic cell heterogeneity in mouse and humans. Cell 179:846-863 DOI: 10.1016/j.cell.2019.09.035 *co-author†co-corresponding author
Duurland C, Brown C, O’Shaughnessy R, Wedderburn L. (2017). CD161+ Tconv and CD161+ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire. Front Immunol; 8: 103
Brown C,* Esterhazy, D, Sarde, A, London, M, Pullabhatla, V, Osma-Garcia, I, al-Bader, R, Ortiz, C, Elgueta, R, Arno, M, de Rinaldis, E, Mucida D, Lord G, Noelle, R. (2015). Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity 42:499-511 *co-corresponding author
Brown C, Noelle R. (2015). Seeing through the dark: New insights into the immune regulatory functions of vitamin A. Eur J Immunol 45:1287–1295
Guo Y, Brown C, Ortiz C, Noelle R. (2015). Leukocyte Homing, Fate and Function are controlled by Retinoic Acid. Physiological Reviews 95: 125-148
Guo Y, Lee Y, Brown C, Zhang W, Usherwood E, Noelle R. (2014). Dissecting the Role of Retinoic Acid Receptor Isoforms in the CD8 Response to Infection. J Immunol 192:3336-3344
Brown C, Wedderburn L. (2014). Mapping autoimmune disease epigenetics: what’s on the horizon? Nat Rev Rheumatol 11:131-132
Brown C, Apps J, Winyard P. (2013). A new generation of academic paediatricians. The Lancet 382:28
Brown C, Apps J, Davies G, Ware N, Fisher J., Winyard P. (2013). Making your way as an academic paediatric trainee in the UK Archives of Disease in Childhood - Education and Practice.
Brown C, Haringman N, Davies C, Gore C, Hussain M, Mieli-Vergani G, Vergani D, Warner JO, Marks SD, Boyle RJ. (2012). High prevalence of food sensitisation in young children with liver disease: a clue to food allergy pathogenesis? Pediatr Allergy Immunol: 23: 770–777.
Pino-Lagos K, Guo Y, Brown C, Alexander M, Elgueta R, Bennett K, De Vries V, Nowak E, Blomhoff E, Sockanathan S, Chandraratna R, Dmitrovsky E, and Noelle R. (2011). A retinoic acid–dependent checkpoint in the development of CD4+ T cell–mediated immunity. J Exp Med; 208:1767-1775