Cell Biology Program
The Alban Ordureau Lab
My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end, we combine cell biological, genome engineering (CRISPR), and biochemical approaches to provide new insights into mechanisms regulating various aspects of cellular homeostasis. Central to our research efforts, we employ and develop multiple quantitative proteomics workflows to examine how flux in signaling systems (e.g., phosphorylation, ubiquitylation, protein translation, degradation, and trafficking) is altered in response to perturbations or disease mutations.
Ordureau, A.†, Kraus, F., Zhang, J., An, H., Park, S., Ahfeldt, T., Paulo, J.A., Harper, J.W.†. (2021) Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy. Molecular Cell. S1097-2765(21)00800-5.
Antico, O.*, Ordureau, A.*, Stevens, M., Singh, F., Nirujogi, R.S., Gierlinski, M., Barini, E., Rickwood, M.L., Prescott, A., Toth, R., Ganley, I.G., Harper, J.W., Muqit, M.M.K. (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Science Advances 7(46):eabj0722.
An, H.*, Ordureau, A.*, Korner, M., Paulo, J.A., Harper, J.W. (2020) Systematic Quantitative Analysis of Ribosome Inventory During Nutrient Stress. Nature 583(7815), 303-309.
Ordureau, A., Paulo, J.A., Zhang, J., An, H., Swatek, K.N., Cannon, J.R., Wan, Q., Komander, D., Harper J.W. (2020) Global landscape and dynamics of Parkin and USP30-dependent ubiquitylomes in iNeurons during mitophagic signaling. Molecular Cell. 77(5):1124-1142.
Alban Ordureau, PhD
- Alban Ordureau explores molecular signaling pathways that regulate cellular homeostasis, with a focus on the ubiquitin and autophagy systems.
- PhD, MRC-PPU - University of Dundee, Scotland, UK
- Post-doctoral training - Harvard Medical School, Boston
- Edward R. and Anne G. Lefler Center Fellow
- Pew Biomedical Scholar
- Kathryn W. Davis Aging Brain Scholar
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Alban Ordureau discloses the following relationships and financial interests:
Nine Square Therapeutics
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