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13 News Items found
In the Lab
Structural biologist Stephen Long in his lab
High-Tech Microscope Reveals Inner Workings of Protein Assembly Machinery

Sloan Kettering Institute investigators have learned how Hedgehog proteins, which are important in both development and cancer, are assembled.
Structure of an intermediate during the homologous recombination reaction.
Wielding Powerful Imaging Tools, MSK Researchers Decipher Process of DNA Repair

The high-resolution views provided by cryo-electron microscopy are helping scientists learn how proteins and DNA collaborate to repair broken DNA.
Regulatory proteins (gold balls) bind to enhancer regions (light blue) and promoter regions (pink) of DNA to form clusters that enable transcription (purple).
Going the Distance: How DNA Enhancers Communicate with Their Target Genes

Scientists at the Sloan Kettering Institute are learning how far-flung regions of genes connect to start the process of making proteins.
Q&A
Structural biologist Christopher Lima
Peering at Biological Molecules: A Conversation with Structural Biology Chair Christopher Lima

Seeing Biological Molecules at the Atomic Level: At Work with Christopher Lima, Structural Biology Chair.
Dinshaw Patel (left) with Zhu Chen, Vice Chairman of the National People’s Congress of China
Dinshaw Patel Receives C.C. Tan Life Science International Collaboration Award

The award recognizes his lifetime contributions to the field of life sciences, especially related to the training of Chinese scientists who have returned to faculty positions in China.
In the Lab
A gray blob marked RAS linked to colorful rods marked ICMT
Deciphering How Membrane Enzymes Work, with a Little Help from Beetles

The atomic structure of an elusive type of membrane protein has finally been solved by scientists at the Sloan Kettering Institute.
Science Byte
Blue cells containing small red dots on a green and black background
Lifeguard on Duty: Looking at DNA Repair under a Microscope

Learn about what DNA repair looks like under a microscope.
Announcement
MSK Symposium Honors Dinshaw Patel, Titan of Structural Biology
MSK Symposium Honors Dinshaw Patel, Titan of Structural Biology

Scientists came to MSK to celebrate the 75th birthday of a leader in the field of structural biology.
Feature
Molecular biologist John Petrini of the Sloan Kettering Institute.
Understanding the DNA-Damage “First Responders”: John Petrini at Work

Scientists know that cancer can result from mistakes in DNA repair. But understanding what controls the repair process itself has been a hard nut to crack.
In the Lab
Pictured: Three-dimensional structure of the protein mTOR
A Recently Revealed Protein Structure Creates New Opportunities for Cancer Research and Drug Design

In an eagerly awaited study, Memorial Sloan Kettering researchers report on the molecular structure of mTOR, a protein commonly mutated in cancer.