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MSK immunologist Ming Li
Sloan Kettering Institute Scientists Solve a 100-Year-Old Mystery about Cancer

Scientists have long known that cancer cells and immune cells have an uncommon hunger for glucose but haven’t understood why. A new study offers an answer.
Francisco Sánchez-Rivera
Confronting a Crisis: How MSK Cancer Geneticists Responded to COVID-19

During World War II, US factories famously converted their operations to support the war effort. COVID-19 instigated something similar among cancer scientists.
Human metastatic melanoma cells in a lymph node. ENPP1, a protein involved in immune evasion, is shown in green.
Taking the STING Out of Cancer: Discovery about How Cancer Cells Evade Immune Defenses Inspires New Treatment Approach

The research identifies a protein called ENPP1 as a potential drug target in the treatment of advanced cancers with chromosome instability.
Dana Pe'er, Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute
Year in Review: Top 10 MSK Cancer Science Breakthroughs of 2020

Take a look back at some of the biggest cancer science stories from this past year.
In the Clinic
Physician-scientist Charles Rudin
Unexpected Finding Reveals New Target for Aggressive Form of Lung Cancer

Researchers discover that a subset of lung adenocarcinomas are aggressive because of mutations that allow them to block ferroptosis, a type of cell death.
Structure of an intermediate during the homologous recombination reaction.
Wielding Powerful Imaging Tools, MSK Researchers Decipher Process of DNA Repair

The high-resolution views provided by cryo-electron microscopy are helping scientists learn how proteins and DNA collaborate to repair broken DNA.
Nadeem Riaz (left) and Jorge Reis-Filho (right)
For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment

Human data and results from mouse experiments suggest that people with BRCA2 mutations may respond well to immunotherapy drugs.
Finding
Systems biologist Joao Xavier in his lab
MSK Study Is the First to Link Microbiota to Dynamics of the Human Immune System

MSK researchers have shown for the first time that the concentration of different types of immune cells in the blood changes in relation to the presence of different bacterial strains in the gut.
In the Lab
SKI cell biologists Junmei Yi and Xuejun Jiang
More Evidence that Cellular ‘Death by Iron’ Could Be Promising Avenue of Cancer Treatment

Cancers with certain mutations are vulnerable to ferroptosis, a form of iron-dependent cell death.
In the Lab
Postdoctoral fellows Linde Miles and Robert Bowman in the lab.
Single-Cell Study Sheds Light on Leukemia’s Family Tree

New research looks at how a series of mutations in normal blood cells can lead to them becoming cancerous and how these mutations accumulate as cancer progresses.