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Finding

Whether a BRCA Mutation Leads to Cancer Depends on Context, Study Finds

By Matthew Tontonoz

Sometimes a BRCA mutation is just along for the ride, rather than driving a tumor’s development.

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Computational biologist Barry Taylor discusses findings of a new study about BRCA genes.

In the Lab

Drug That Hits CAR T Snooze Button Can Quiet a Cytokine Storm

By Matthew Tontonoz

An FDA-approved drug used to treat leukemia can serve as a temporary off switch for CAR T cells, MSK scientists have found.

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cartoon of man hitting a snooze button

In the Lab

Scientists Use CRISPR to Learn How Cells Make Decisions

By Matthew Tontonoz

The genome-editing technique uncovered several genes previously not known to influence embryonic development.

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Fluorescent red and green cells

In the Lab

Research Clarifies How IDH Mutations Cause Cancer

By Julie Grisham

The MSK team’s goal was to get at the underlying defects in cells that these mutations cause.

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DNA winding around histones

Announcement

GSK Students Win Grants to Fund Innovative Cancer Research

By Esther Napolitano

Two outstanding graduate students from the Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences (GSK) have been awarded federal funding to pursue promising cancer research.

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In the Lab

Stem Cells Stay “Young” on a Fat-Free Diet

By Jim Stallard

Researchers have discovered a simple way to keep stem cells in a more flexible state for research and potential treatments.

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Colored scanning electron micrograph of a clump of pluripotent stem cells.

In the Lab

Researchers Unravel the Biology of a Distinct Prostate Cancer Subtype

By Matthew Tontonoz

Mutations in a gene called FOXA1 are responsible for a distinct class of prostate cancer tumors, MSK researchers have found.

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MSK cancer researchers Elizabeth Adams, Charles Sawyers, and Rohit Bose

In The Lab

Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

By Julie Grisham

Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice.

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An illustration of a samurai and a crab.

In the Lab

Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

By Matthew Tontonoz

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.

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Immune cells surrounding a cancer cell

In The Lab

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

By Matthew Tontonoz

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

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Two clusters of colored blobs with a diagram in the middle