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Science Byte

Scientists Discover Keys to Immune Response against Anthrax

By Jim Stallard

Researchers clarify how the immune system activates an inflammatory defense against pathogens.

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Ribbon diagram of an anthrax protein.

Helping Scientists Face Adversity through Resilience and Self-Care

Scientists in all stages of their careers gathered recently to hear from Sharon Milgram speak about how attitudes and behaviors that can get in the way of a successful career.

  • Tuesday, April 9, 2019

In the Lab

Scientists Rewrite the Textbook of Organ Development, One Cell at a Time

By Matthew Tontonoz

A large study that analyzed nearly 120,000 cells in a developing mouse embryo is full of surprises.

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In this fluorescent microscopy image of endoderm tissue from a mouse embryo, cell membranes are red, cell nuclei are blue, and extra-embryonic endoderm cells are green (they appear turquoise because blue and green are merged).

Feature

An Old Protein Gets a New Look: Researchers Target TGF-ß to Make Immunotherapy More Effective

By Julie Grisham

Drugs that block the action of TGF-ß may make checkpoint inhibitors more effective.

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Model of TGF-beta molecule

In the News

AACR 2019 Research Roundup: Nanosensors for Cancer, New Immunotherapy Targets, a Road Map of Metastasis, and CAR T Fratricide

By Matthew Tontonoz Jim Stallard

Read our key takeaways from the second half of the American Association for Cancer Research’s 2019 annual meeting.

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an illustration of cancer metastasis

In the News

AACR 2019 Research Roundup: Pancreatic Cancer Immunotherapy, Prostate Cancer Drug Resistance, Insight into Inherited Cancer Mutations

By Jim Stallard Julie Grisham Matthew Tontonoz

Read up on the latest developments in several important areas of cancer research emerging from the 2019 American Association for Cancer Research annual meeting.

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AACR 2019 Annual Meeting

In the Clinic

CAR Therapy for Solid Tumors Draws Attention at Annual Cancer Conference

By Matthew Tontonoz

Results from a clinical trial indicate that an experimental CAR therapy for mesothelioma is safe.

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Scientific Image

In the Lab

A Death Wish That Allows Worms to Thrive — and What It Tells Us About Cancer Biology

By Julie Grisham

Researchers discover that a curious type of cell death plays a role in normal development.

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Microscopic image of cancer cells and C. elegans cells undergoing entosis.

In th Lab

Cellular “Garbage Collectors” Are Key to Cancer’s Growth

By Matthew Tontonoz

A new study suggests a way to target cancer by interfering with its system of waste removal.

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A cartoon depicting a cleaning crew

In The Lab

Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds

By Julie Grisham Matthew Tontonoz

MSK researchers have identified a compound that kills glioblastoma cells using a mechanism that’s completely different from earlier treatments.

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Enhanced MRI of a glioblastoma