Human Oncology & Pathogenesis Program
The Samuel Bakhoum Lab
Research
Assistant Professor
The Bakhoum lab focuses on understanding the role of chromosomal instability (CIN) in tumor evolution and progression. CIN is a hallmark of human cancer and it is associated with poor prognosis, metastasis, and therapeutic resistance. It results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing genomic double-stranded DNA into the cytosol, engaging cytosolic DNA-sensing antiviral innate immune pathways. Our team has also identified CIN as an important driver of epigenetic heterogeneity and reprogramming in cancer. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment. Our lab is interested in dissecting the mechanisms linking CIN and cancer progression and translating these discoveries into novel therapeutic strategies.
Research Projects
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Samuel Bakhoum, MD, PhD
Assistant Member, Human Oncology and Pathogenesis Program; Assistant Attending, Department of Radiation Oncology
Assistant Professor
- Physician-scientist Samuel Bakhoum studies the role of chromosomal instability in tumor evolution and metastasis.
- MD, Dartmouth Medical School
- PhD, Dartmouth College
- samuel.bakhoum@gmail.com
- Email Address
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- Physician profile
Members
Weill Cornell Graduate Student
Medical Oncology Fellow
Research Technician (mucosal melanoma translational program)
Postdoctoral Fellow
Postdoctoral Fellow
Senior Research Technician
Visiting Professor and Collaborator
Weill Cornell Medical Student
Postdoctoral Researcher (co-mentored by Dr. Atif Khan and Dr. Simon Powell)
Postdoctoral Fellow
Administrative Assistant
Postdoctoral Fellow
Lab Alumni
Administrative Assistant
Senior Research Technician
Current institution: Weill Cornell Medicine
Holman Research Fellow
Administrative Assistant
Lab Affiliations
Achievements
- Josie Robertson Investigator (2018-2023)
- AAAS Martin and Rose Wachtel Cancer Research Award (Honorable mention)
- NIH Director’s Independence Award (2018-2023)
- Blavatnik Regional Award for Young Scientists (Finalist) (2018)
- Tri-Institutional Breakout Prize (2018)
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- Burroughs Wellcome Fund Career Award for Medical Scientists (2018)
- NextGen Stars, American Association for Cancer Research (AACR) (2018)
- Breast Cancer Breakthrough Award, Department of Defense (2016)
- ASCI/AAP Outstanding Young Investigator Award (2011)
- Norton B. Gilula Award, the American Society for Cell Biology (2008)