Human Oncology & Pathogenesis Program

The Samuel Bakhoum Lab

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Research

Samuel Bakhoum, MD, PhD
Samuel Bakhoum, MD, PhD
Assistant Member, Human Oncology and Pathogenesis Program; Assistant Attending, Department of Radiation Oncology

Assistant Professor

The Bakhoum lab focuses on understanding the role of chromosomal instability (CIN) in tumor evolution. CIN is a hallmark of human cancer and it is associated with poor prognosis, metastasis, and therapeutic resistance. It results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing genomic double-stranded DNA into the cytosol, engaging cytosolic DNA-sensing antiviral innate immune pathways. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment.

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Research Projects

Samuel Bakhoum Lab Group

Publications

People

Samuel Bakhoum, MD, PhD

Samuel Bakhoum, MD, PhD

Assistant Member, Human Oncology and Pathogenesis Program; Assistant Attending, Department of Radiation Oncology

Assistant Professor

  • Physician-scientist Samuel Bakhoum studies the role of chromosomal instability in tumor evolution and metastasis.
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Physician profile

Members

Albert Agustinus
Albert Agustinus

Weill Cornell Graduate Student

Emma Armstrong

Research Technician (mucosal melanoma translational program)

Melody Di Bona
Melody Di Bona

Postdoctoral Fellow

Mercedes Duran
Mercedes Duran

Senior Research Technician

Sergi Elizalde
Sergi Elizalde

Visiting Professor and Collaborator

John Kwon
John Kwon

Weill Cornell Medical Student

Emanuele Lettera

Postdoctoral Researcher (co-mentored by Dr. Atif Khan and Dr. Simon Powell)

Jun Li
Jun Li

Postdoctoral Fellow

Xingzhe Li

Holman Research Fellow

Anestashia Melford

Administrative Assistant

Nimi Vashi
Nimi Vashi

Postdoctoral Fellow

Lab Alumni
Giscard Barbier

Administrative Assistant

Julie-Ann Cavallo-Fleming
Julie-Ann Cavallo-Fleming

Senior Research Technician

Ninjit Dhanota
Ninjit Dhanota

Current institution: Weill Cornell Medicine

Lab Affilations

Achievements

  • AAAS Martin and Rose Wachtel Cancer Research Award (Honorable mention)
  • NIH Director’s Independence Award (2018-2023)
  • Josie Robertson Investigator (2018-2023)
  • Blavatnik Regional Award for Young Scientists (Finalist) (2018)
  • Tri-Institutional Breakout Prize (2018)
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  • Burroughs Wellcome Fund Career Award for Medical Scientists (2018)
  • NextGen Stars, American Association for Cancer Research (AACR) (2018)
  • Breast Cancer Breakthrough Award, Department of Defense (2016)
  • ASCI/AAP Outstanding Young Investigator Award (2011)
  • Norton B. Gilula Award, the American Society for Cell Biology (2008)

Open Positions

Computational Biology/Cancer Bioinformatics Positions

The Bakhoum Lab is seeking candidates with a strong background in computational biology and cancer bioinformatics.

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General Opportunity

Inquiries about postdoctoral fellowships, medical research fellowships, graduate student rotations, or technician positions should be directly addressed to BakhoumLabPositions@gmail.

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Postdoctoral Positions

Postdoctoral positions are currently available for high motivated candidates with a background in tumor biology, tumor immunology, or cell biology.

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