Human Oncology & Pathogenesis Program

The Samuel Bakhoum Lab

Research

Samuel Bakhoum, MD, PhD
Samuel Bakhoum, MD, PhD
Associate Member, Human Oncology and Pathogenesis Program; Associate Attending, Department of Radiation Oncology

Assistant Professor

The Bakhoum lab focuses on understanding the role of chromosomal instability (CIN) in tumor evolution and progression. CIN is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, Our team has identified numerous mechanisms by which CIN drives cancer progression. First, we found that CIN promotes inflammatory signaling by introducing genomic double-stranded DNA into the cytosol, engaging cytosolic DNA-sensing antiviral innate immune pathways. Instead of eliciting anti-tumor immunity, CIN-induced chronic inflammation promotes immune suppression and metastasis. In addition, we also CIN as an potent driver of epigenetic heterogeneity and reprogramming through chromosome encapsulation in micronuclei. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment. Our lab is interested in dissecting the mechanisms linking CIN and cancer progression and translating these discoveries into novel therapeutic strategies.

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Research Projects

Samuel Bakhoum Lab Group

Publications Highlights

People

Samuel Bakhoum, MD, PhD

Samuel Bakhoum, MD, PhD

Associate Member, Human Oncology and Pathogenesis Program; Associate Attending, Department of Radiation Oncology

Assistant Professor

  • Physician-scientist Samuel Bakhoum studies the role of chromosomal instability in tumor evolution and metastasis.
  • MD, Dartmouth Medical School
  • PhD, Dartmouth College
[email protected]
Email Address
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Physician profile

Members

Albert Agustinus
Albert Agustinus

Weill Cornell Graduate Student

Duaa Al-Rawi
Duaa Al-Rawi

Medical Oncology Fellow

Daniel Bronder
Daniel Bronder

Postdoctoral Fellow

Xuelan Chen

Postdoctoral Fellow

Melody Di Bona
Melody Di Bona

Postdoctoral Fellow

Mercedes Duran
Mercedes Duran

Senior Research Technician

Christy Hong
Christy Hong

Graduate Research Assistant

Emanuele Lettera
Emanuele Lettera

Postdoctoral Researcher (co-mentored by Dr. Atif Khan and Dr. Simon Powell)

Jun Li
Jun Li

Postdoctoral Fellow

Sarina McElduff

MSK Bridge Scholar

Sierra Norfleet

Administrative Assistant

Danguole Norkunaite

Research Technician

Lab Alumni
Emma Armstrong
Emma Armstrong

Research Technician (mucosal melanoma translational program)

Giscard Barbier

Administrative Assistant

Julie-Ann Cavallo-Fleming
Julie-Ann Cavallo-Fleming

Senior Research Technician

Ninjit Dhanota
Ninjit Dhanota

Current institution: Weill Cornell Medicine

Sergi Elizalde
Sergi Elizalde

Visiting Professor and Collaborator

John Kwon
John Kwon

Weill Cornell Medical Student

Xingzhe Li

Holman Research Fellow

Anestashia Melford

Administrative Assistant

Nimi Vashi
Nimi Vashi

Postdoctoral Fellow

Lab Affiliations

Achievements

  • Mark Foundation Emerging Leader Award (2023-2026)
  • BioInnovation Institute & Science Magazine Prize (Finalist) (2023)
  • 20 Under 40 Next Generation of Biotech Leaders by Endpoint News (2022)
  • Josie Robertson Investigator (2018-2023)
  • AAAS Martin and Rose Wachtel Cancer Research Award (Honorable mention)
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  • NIH Director’s Independence Award (2018-2023)
  • Blavatnik Regional Award for Young Scientists (Finalist) (2018)
  • Tri-Institutional Breakout Prize (2018)
  • Burroughs Wellcome Fund Career Award for Medical Scientists (2018)
  • NextGen Stars, American Association for Cancer Research (AACR) (2018)
  • Breast Cancer Breakthrough Award, Department of Defense (2016)
  • ASCI/AAP Outstanding Young Investigator Award (2011)
  • Norton B. Gilula Award, the American Society for Cell Biology (2008)

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Samuel Bakhoum discloses the following relationships and financial interests:

  • Meliora Therapeutics
    Equity; Professional Services and Activities
  • Volastra Therapeutics Inc.
    Equity; Fiduciary Role / Position; Intellectual Property Rights; Professional Services and Activities

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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