Molecular Biology Program

The Kenneth Marians Lab

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Research

Ken Marians
Kenneth J. Marians, PhD


Professor

Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division. Our studies on the consequences of replication fork blockage and restart utilize purified replication, recombination, and transcription proteins in various well-defined systems reconstituted in vitro that model all steps of these events. Our studies on chromosome condensation and segregation utilize a combination of biochemical, cell biological, and molecular genetic approaches.

Research Projects

The Ken Marians Lab

Featured News

Feature
Memorial Sloan Kettering molecular biologist Jerard Hurwitz
Remembering Jerard Hurwitz, a Giant of Molecular Biology

Q&A
Kenneth Marians and Louis V. Gerstner, Jr.
Reflecting on 15 Years of Leadership: An Interview with Outgoing GSK Dean Ken Marians

In the News
Molecular biologist Ken Marians and cell biologist Michael Overholtzer
MSK’s Graduate School Welcomes New Dean, Bids Farewell to Its First

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Publications

M. K. Gupta, C. P. Guy, J. T. P. Yeeles, J. Atkinson, H. Bell, R. G. Lloyd, K. J. Marians, and P. McGlynn, Protein-DNA Complexes Are the Primary Source of Replication Fork Pausing in Escherichia coli. Proc. Nat’l. Acad. Sci. U. S. A., 110, 7252-7257 (2013). PMCID: PMC3645559.

J. T. P. Yeeles and K. J. Marians, Dynamics of Leading-strand Lesion Skipping by the Replisome, Mol. Cell, 52, 855-865 (2013). PMCID: PMC3877186.

S. Gupta, J. T. P. Yeeles, and K. J. Marians, Regression of Replication Forks Stalled by Leading-strand Template Damage I. Both RecG and RuvAB Catalyze Regression, but RuvC Cleaves the Holliday Junctions Formed by RecG Preferentially. J. Biol. Chem. 289, 28376-28387 (2014). PMCID: PMC4192490.

C. B. Gabbai, J. T. P. Yeeles, and K. J. Marians, Replisome–mediated Trans-lesion Synthesis and Leading-strand Lesion Skipping are Competing Bypass Mechanisms. J. Biol. Chem. 289, 32811-32823 (2014). PMCID: 4239630.

J. E. Graham, K. J. Marians*, and S. C. Kowalczykowski*, Independent and Stochastic Action of DNA Polymerases in the Replisome. Cell, 169, 1201-1213 (2017). *Co-corresponding authors. PMCID: PMC5548433

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People

Ken Marians

Kenneth J. Marians, PhD



Professor

  • Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.
  • PhD, Cornell University
kmarians@sloankettering.edu
Email Address
212-639-5890
Office Phone

Members

Jan-Gert Brüning
Jan-Gert Brüning

Postdoctoral Fellow

Avradip Chatterjee
Avradip Chatterjee

Postdoctoral Fellow

Rupesh Kumar
Rupesh Kumar

Postdoctoral Fellow

Philip Nevin
Philip Nevin

Postdoctoral Fellow

Soon Bahng
Soon Bahng

Research Technician

Chong Lee
Chong Lee

Research Technician

Pearl Nurse

Senior Research Technician

Lab Alumni
Sarah Bigot

Research Fellow

Carolina Gabbai

Graduate Student

Ryo Hayama

Graduate Student

Ram Madabhushi

Graduate Student

Brenda Perez

Research Fellow

Lab Affilations

Open Positions

Career Opportunities

Applicants interested in career opportunities in the Marians Laboratory should send their resume to kmarians@sloankettering.

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Kenneth J. Marians discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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