Molecular Biology Program
The Kenneth Marians Lab
Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division. Our studies on the consequences of replication fork blockage and restart utilize purified replication, recombination, and transcription proteins in various well-defined systems reconstituted in vitro that model all steps of these events. Our studies on chromosome condensation and segregation utilize a combination of biochemical, cell biological, and molecular genetic approaches.
M. K. Gupta, C. P. Guy, J. T. P. Yeeles, J. Atkinson, H. Bell, R. G. Lloyd, K. J. Marians, and P. McGlynn, Protein-DNA Complexes Are the Primary Source of Replication Fork Pausing in Escherichia coli. Proc. Nat’l. Acad. Sci. U. S. A., 110, 7252-7257 (2013). PMCID: PMC3645559.
S. Gupta, J. T. P. Yeeles, and K. J. Marians, Regression of Replication Forks Stalled by Leading-strand Template Damage I. Both RecG and RuvAB Catalyze Regression, but RuvC Cleaves the Holliday Junctions Formed by RecG Preferentially. J. Biol. Chem. 289, 28376-28387 (2014). PMCID: PMC4192490.
C. B. Gabbai, J. T. P. Yeeles, and K. J. Marians, Replisome–mediated Trans-lesion Synthesis and Leading-strand Lesion Skipping are Competing Bypass Mechanisms. J. Biol. Chem. 289, 32811-32823 (2014). PMCID: PMC4239630.
Kenneth J. Marians, PhD
- Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.
- PhD, Cornell University
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