Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division. Our studies on the consequences of replication fork blockage and restart utilize purified replication, recombination, and transcription proteins in various well-defined systems reconstituted in vitro that model all steps of these events. Our studies on chromosome condensation and segregation utilize a combination of biochemical, cell biological, and molecular genetic approaches.
Kenneth J. Marians, PhD
Professor
Research Focus
Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.Education
PhD, Cornell University- Office Phone: 212-639-5890
- Office Fax: 212-717-3627
- Lab Phone: 212-639-5891 / 5892
- Lab Fax: 212-717-3627
Lab Members
Postdoctoral Fellow
Postdoctoral Fellow
Postdoctoral Fellow
Postdoctoral Fellow
Research Technician
Research Technician
Senior Research Technician
Publications
- M. K. Gupta, C. P. Guy, J. T. P. Yeeles, J. Atkinson, H. Bell, R. G. Lloyd, K. J. Marians, and P. McGlynn, Protein-DNA Complexes Are the Primary Source of Replication Fork Pausing in Escherichia coli. Proc. Nat’l. Acad. Sci. U. S. A., 110, 7252-7257 (2013). PMCID: PMC3645559.
- J. T. P. Yeeles and K. J. Marians, Dynamics of Leading-strand Lesion Skipping by the Replisome, Mol. Cell, 52, 855-865 (2013). PMCID: PMC3877186.
