Experimental Drug for Low-Grade Glioma With IDH Gene Mutation Shows Promise
A new experimental drug could be an effective treatment for some people with low-grade glioma.
Treatment for Low-Grade Glioma Advances to Phase 3 Clinical Trial
According to findings from a research team led by study first-author Ingo Mellinghoff, MD, Chair of MSK’s Department of Neurology: vorasidenib and ivosidenib reduced concentrations of 2-HG by more than 90%, were well-tolerated, and showed encouraging tumor responses amongst 49 patients enrolled in a multisite trial between April 2019 and April 2020. Vorasidenib showed greater brain penetration than ivosidenib. Based on the phase 1 trial results, vorasidenib was advanced to a phase 3 trial.
In the Clinic
Analyzing Spinal Fluid Could Guide Brain Tumor Diagnosis and Treatment
Cancer DNA taken from spinal fluid could serve as a liquid biopsy that provides information on brain tumor mutations.
Brain Trust: 8 Questions with Ingo Mellinghoff
Ingo Mellinghoff is optimistic about the future of brain cancer treatments as the new Chair of MSK’s Department of Neurology.
Ingo Mellinghoff Named the Evnin Family Chair in Neuro-Oncology
Physician-scientist Ingo Mellinghoff has been designated the incumbent of the Evnin Family Chair in Neuro-Oncology. Established through the generosity ...
Memorial Sloan Kettering Discoveries in Personalized Medicine Highlighted at Major Cancer Research Meeting; Investigators Honored
The American Association for Cancer Research (AACR), the world's oldest and largest professional organization dedicated to advancing cancer research, held its 2012 annual meeting in Chicago.
In the Lab
Studies Show How Certain Gene Mutations May Promote Cancer
Two Memorial Sloan Kettering studies provide new clues about genetic mutations that affect cell behavior and play a role in several types of cancer.
Researchers Uncover Molecular Interactions in Common Form of Brain Cancer
A multicenter team led by Memorial Sloan Kettering neurologist and researcher Ingo K. Mellinghoff has uncovered the relationship between two proteins that play a critical role in glioblastoma, the most common form of brain cancer.