The Gretchen Diehl Lab
The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within the intestine impair barrier repair, amplifying damage and potentially lead to systemic infection or chronic inflammatory disease including inflammatory bowel disease (IBD). We find that the intestinal microbiota and dietary factors can promote or inhibit proper immune regulation. As such, we seek to define molecular and cellular pathways regulated by the microbiota, dietary, and tissue factors that are required to maintain homeostasis within the intestine. In defining upstream signals, we are working to understand microbial pathways and how they modulate tissue immunity. In parallel, we seek to delineate how these networks are disrupted in inflammatory conditions.
Hill AA, Kim M, Zegarra-Ruiz DF, Chang LC, Norwood K, Assié A, Wu WH, Renfroe MC, Song HW, Major AM, Samuel BS, Hyser JM, Longman RS, Diehl GE*. Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI Insight. 2023 Feb 8 ;8(3):e164489.
Zegarra Ruiz DF, Kim DV, Norwood K, Saldana-Morales FB, Kim M, Ng C, Callaghan R, Uddin M, Chang LC, Longman RS, Diehl GE*. Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer. Gut Microbes. 2022 Jan-Dec ;14(1):2119054.
Gretchen Diehl, PhD
Catherine and Frederick R. Adler Chair for Junior Faculty
- The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.
- PhD, University of California, Berkeley
- [email protected]
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Gretchen Diehl discloses the following relationships and financial interests:
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