Immunology Program

The Gretchen Diehl Lab

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Research

The Gretchen Diehl Lab
Gretchen Diehl, PhD


Associate Professor

The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within the intestine impair barrier repair, amplifying damage and potentially lead to systemic infection or chronic inflammatory disease including inflammatory bowel disease (IBD). We find that the intestinal microbiota and dietary factors can promote or inhibit proper immune regulation. As such, we seek to define molecular and cellular pathways regulated by the microbiota, dietary, and tissue factors that are required to maintain homeostasis within the intestine. In defining upstream signals, we are working to understand microbial pathways and how they modulate tissue immunity. In parallel, we seek to delineate how these networks are disrupted in inflammatory conditions.

The Gretchen Diehl Lab

Publications

Kim M., Hill A.A., Wu W-J., Diehl G.E., 2019. Intestinal microbes direct CX3CR1+ cells to balance intestinal immunity. Gut Microbes. 10: 540-546. doi: 10.1080/19490976.2018.1559683

Yuan X., Chang C-Y., You R., Shan M., Gu B-H., Madison M., Diehl, G.E., Perusich S., Song L-Z., Cornwell L., Rossen R., Wetsel R.A., Rajapakshe K., Coarfa C., Eltzschig H.K., Corry D., Kheradmand K., 2019. Cigarette smoke-induced reduction of C1q promotes emphysema. JCI Insight. 5. pii:124317. PMCID: PMC6629245.

Kim M., Gu B., Maddison M.C., Song H., Norwood K., Hill A.A., Wu W-J, Corry D., Kheradmand F., Diehl G.E., 2019. Cigarette Smoke Induces Intestinal Inflammation via a Th17 cell-Neutrophil Axis. Frontiers in Immunology. PMCID: PMC6361762.

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People

The Gretchen Diehl Lab

Gretchen Diehl, PhD



Associate Professor

  • The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.
  • PhD, University of California, Berkeley

Members

Gretchen Diehl, PhD
Gretchen Diehl

Associate Member

Lin-Chun Chang
Lin-Chun Chang

Senior Research Scientist

Daniel Zegarra Ruiz
Daniel Zegarra Ruiz

Postdoctoral Associate

Fatima Saldana Morales
Fatima Saldana Morales

Graduate Student

Dasom Kim
Dasom Kim

Graduate Student

Ming-Ting Tsai
Ming-Ting Tsai

Graduate Student

Wan-Jung Wu
Wan-Jung Wu

Graduate Student

Lab Affilations

Open Positions

Postdoctoral positions

Postdoctoral positions are currently available to study mechanisms of microbiome influence on host immunity utilizing mouse models.

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