Our laboratory is interested in understanding the molecular mechanism of DNA replication in eukaryotic cells. DNA replication is the fundamental process by which all living organisms copy their DNA and preserve the integrity of their genomes between generations. In particular we are interested in the initiation of DNA replication, the first and most critically regulated step in the DNA replication cycle. We want to understand how the proteins involved in initiation coordinate their activities to direct the formation of replication forks, using budding yeast, Saccharomyces cerevisiae, as a model for eukaryotic cells.
Dirk Remus, PhD
Research FocusMolecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.
EducationPhD, University of California, Berkeley
- Gan H, Yu C, Devbhandari S, Sharma S, Han J, Chabes A, Remus D, Zhang Z. Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress. Mol Cell. 2017 Oct 19;68(2):446-455.e3. doi: 10.1016/j.molcel.2017.09.018. Epub 2017 Oct 12.
- Devbhandari S, Jiang J, Kumar C, Whitehouse I, Remus D. Chromatin Constrains the Initiation and Elongation of DNA Replication. Mol Cell. 2017 Jan 5;65(1):131-141. doi: 10.1016/j.molcel.2016.10.035. Epub 2016 Dec 15.