Molecular Biology Program
The Dirk Remus Lab
We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated chromatin states. As chromosomes are the carriers of both the genetic and epigenetic information, faithful chromosome replication is of fundamental importance for genome maintenance during normal cell proliferation. Accordingly, defects in chromosome replication are a major driver of the genomic instability observed in cancer cells. To understand the molecular mechanisms by which eukaryotic cells carry out and monitor accurate genome replication we employ a fully reconstituted DNA replication system based on purified proteins from the budding yeast, S. cerevisiae. Research projects are focused on the mechanistic characterization of the DNA replication machinery, the mechanism of replication-coupled chromatin assembly, and the control of DNA replication by checkpoint genome surveillance pathways.
Scherr MJ, Wahab SA, Remus D, Duderstadt KE. Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase. Cell Rep. 2022 Mar 22;38(12):110531. doi: 10.1016/j.celrep.2022.110531.
Castaneda JC, Schrecker M, Remus D*, Hite RK*. Mechanisms of loading and release of the 9-1-1 checkpoint clamp. Nat Struct Mol Biol. 2022 Mar 21. doi: 10.1038/s41594-022-00741-7. Epub ahead of print. *corresponding author
Philip J, Örd M, Silva A, Singh S, Diffley JF, Remus D, Loog M, Ikui AE. Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae. Elife. 2022 Feb 10;11:e74437. doi: 10.7554/eLife.74437. PMCID: PMC8830886.
Kumar, C., Batra, S., Griffith, J.D., and Remus, D. (2021). The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions. eLife 2021 Sep 8;10:e72286.
Abd Wahab S and Remus D. Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53. eLife 2020; Jul 23;9:e58571. doi: 10.7554/eLife.58571.
Dirk Remus, PhD
- Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.
- PhD, University of California, Berkeley
- Louis V. Gerstner, Jr. Young Investigator Award, Memorial Sloan Kettering Cancer Center (2011)
- Long-Term Fellow, EMBO (2006)
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