Structural Biology Program
The Dinshaw Patel Lab
Our group applies crystallographic and solution NMR techniques to investigate macromolecular-mediated recognition, regulation, and catalysis. The major thrust of the laboratory is currently in the structural biology of RNA silencing and epigenetic regulation (histone and DNA methylation marks). Significant efforts are also under way toward a molecular understanding of RNA-mediated events involving riboswitches and ribozymes, as well as protein-RNA recognition events impacting on disease syndromes. A new project addvesses structure-function studies of cytoplasmic metazoan nucleic acid sensors and their cyclic dinucleotide second messengers that activate the innate immune response. Other projects include higher-order DNA architectures and the DNA damage. Finally, our group also studies the molecular basis of glycosphingolipid and phospholipid binding specificity.
Sun, X-J., Wang, Z., Wang, L., Jiang, Y., Chen, W-Y., Melnick, A., Patel, D. J., Nimer, S. D. & Roeder, R. G. (2013). A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature 500, 93-97.
Simanshu, D. K., Kamlekar, R. K., Wijesinghe, D. S., Zou, X., Zhai, X., Mishra, S. K., Molotkovsky, J. G., Malinina, L., Hincliffe, E. H., Chalfant, C. E., Brown, R. E. & Patel, D. J. (2013). Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 500, 463-467.
Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A., Jones, R. A., Hartmann, G., Tuschl, T. and Patel, D. J. (2013). Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107.
Johnson, L. M., Du, J., Hale, C. J., Bischof, S., Feng, S., Chodavarapu, R. K., Zhong, X., Marson, G., Pellergrini, M., Segal, D. J., Patel, D. J. and Jacobsen, S. E. (2014). SRA/SET domain proteins link RNA polymerase V occupancy to DNA methylation. Nature 507, 124-128.
Dinshaw Patel, PhD
- The Patel laboratory studies the structural biology of macromolecular recognition, including RNA catalysis, RNA interference, and bypass of DNA damage.
- PhD, New York University
Lab News & Events
This seminar will take place at RRL-116 and by Zoom webinar.
Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
New York, NY 10065
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Dinshaw Patel discloses the following relationships and financial interests:
Southern University of Science and Technology
Provision of Services (uncompensated)
Intellectual Property Rights
Provision of Services (uncompensated)
Provision of Services
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