Structural Biology Program
The Alexandros Pertsinidis Lab
Our mission is the development of a “new” generation of optical imaging technologies to enable advances in two hitherto difficult-to-investigate areas: the real-time analysis of macromolecular interactions and motions at the nanometer scale in vivo and the three-dimensional architecture of complex molecular machines and of subcellular ultrastructure, in situ. We are also refining and applying ultrahigh-resolution spectroscopy techniques to dissect multistep complex biochemical processes using in vitro reconstituted single-molecule assays.
Jieru Li, Ankun Dong, Kamola Saydaminova, Hill Chang, Guanshi Wang, Hiroshi Ochiai, Takashi Yamamoto and Alexandros Pertsinidis. Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells, Cell (2019).
Alexandros Pertsinidis, PhD
Professor, Biochemistry and Structural Biology Program
- The Pertsinidis laboratory uses single-molecule approaches to understand gene transcription and the function of complex macromolecular machines inside live cells.
- PhD, Brown University
- Director’s New Innovator Award, National Institutes of Health (2012)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Alexandros Pertsinidis discloses the following relationships and financial interests:
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