The Joyner lab studies how genes regulate the cell behaviors (proliferation, differentiation, migration) that underlie organ development, tissue repair and cancer. They focus on the brain where stem cells must produce hundreds of cell types at the right times and in the correct numbers, and the cells then migrate to the correct positions and synapse with partners. The lab uses sophisticated mouse genetics approaches to probe how cell-cell communication and cell intrinsic genetic programs determine the way by which normal cerebellar circuitry is established and regulates behaviors, or are disrupted in diseases including cancer.
Alexandra Joyner, PhD
Professor
Research Focus
The Joyner laboratory studies the involvement of Hedgehog signaling and transcription factors in cerebellum development, regeneration and cancer.Education
PhD, University of Toronto- Office Phone: 212-639-3962
- Lab Phone: 212-639-3980
Lab Members
Postdoctoral Research Fellow - NYSTEM Training Award at the CSCB
Postdoctoral Research Fellow
Graduate Student
Graduate Student
SKI Lead Admin
Research Fellow
Graduate Student
Neuro-oncologist
Senior Research Assistant
Senior Research Technician
- Bayin N.S., Wojcinski A., Mourton A., Saito H., Suzuki N., Joyner A.L. (2018). Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons. Elife. doi: 10.7554/eLife.39879.
- Roselló-Díez A., Madisen L., Bastide S., Zeng H., Joyner A.L. (2018). Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice. PLoS Biol. doi: 10.1371/journal.pbio.2005086.
