Developmental Biology Program

The Alexandra Joyner Lab

Research

Alexandra Joyner, PhD

Professor

The Joyner lab studies how genes regulate the cell behaviors (proliferation, differentiation, migration) that underlie organ development, tissue repair and cancer. They focus on the brain where stem cells must produce hundreds of cell types at the right times and in the correct numbers, and the cells then migrate to the correct positions and synapse with partners. The lab uses sophisticated mouse genetics approaches to probe how cell-cell communication and cell intrinsic genetic programs determine the way by which normal cerebellar circuitry is established and regulates behaviors, or are disrupted in diseases including cancer.

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Research Projects

Featured News

At Work: Developmental Biologist Alexandra Joyner

Alexandra Joyner Elected to the Institute of Medicine

Tuesday, December 1, 2009

Publications

Wojcinski, A., Lawton, A., Bayin, N.S., Lao, Z., Stephen, D. and Joyner, A.L. (2017) Cerebellar granule cell replenishment post-injury by adaptive reprogramming of Nestin+ progenitors. Nature Neuroscience, 20:1361-1370.

Tan, I.-L.*, Wojcinski, A.*, Rallapalli, H., Lao, Z., Sanghrajka, R.M., Stephen, D., Volkova, E., Korshunov, A., Remke, M., Taylor, M., Turnbull, D.H., and Joyner, A.L. (2018) Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation. PNAS, 115:3392-2297.

Bayin, N.S., Wojcinski, A., Aurelien Mourton, Hiromitsu Saito, Noboru Suzuki, and Joyner, A.L. (2018) Age-dependent dormant progenitors are stimulated by injury to regenerate Purkinje neurons. eLife. 7. e39879. doi: 10.7554/eLife.39879

Lawton, A., Engstrom, T., Rohrbach, D., Mamou, J., Turnbull, D.H., Zhang, T., Schwarz, J. and Joyner, A.L. (2019) Brain folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern. eLife, 8. pil: e45019.

Willett, R.T*., Bayin, N.S.*, Lee, A.S.*, Krishnamurthy, A.*, Wojcinski, A.*, N., N.S., Lao, Z., Stephen, D., Rosello-Diez, A., Dauber, K.L., Orvis, G.D., Wu, Z., Tessier-Lavigne, M. and Joyner, A.L. (2019) Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cells and organ growth. eLife, Nov 19;8. pii: e50617

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People

Alexandra Joyner, PhD

Professor

The Joyner laboratory studies the involvement of Hedgehog signaling and transcription factors in cerebellum development, regeneration and cancer.
PhD, University of Toronto

joynera@mskcc.org: Email Address
212-639-3962: Office Phone

Members

N. Sumru Bayin
Postdoctoral Research Fellow

Salsabiel El Nagar
Postdoctoral Research Fellow

Yinwen Liang, PhD — Yinwen Liang
Research Associate

Reeti Mayur Sanghrajka, Graduate Student — Reeti Mayur Sanghrajka
Graduate Student

Zhimin (Jimmy) Lao
Senior Research Assistant

Daniel Stephen
Senior Research Technician

Lab Affiliations

Get in Touch

joynera@mskcc.org

Lab Head Email
212-639-3962

Office Phone
212-639-3980

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Alexandra Joyner discloses the following relationships and financial interests:

Science Advances
Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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