Education
Current Position
Scientist, Yale University, New Haven, CT, USA
Honors & Awards
- Recipient of the Kravis Women in Science Endeavor Childcare Grant (2020 and 2021)
Publications
Fan J, Dhingra N, Yang T, Yang V, Zhao X (2024) Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response. bioRxiv 2024.03.28.587206
Kuppa S, Deveryshetty J, Chadda R, Mattice J, Pokhrel N, Patterson A, Pangeni A, Dhingra N, Sadauskas MK, Gyawali P, Balci H, Ha T, Zhao X, Bothner B, and Antony E (2022) Configurational stapling of RPA by Rtt105 prevents untimely interactions with DNA metabolic proteins. Nat Commun 13:5152
Dhingra N, Zhao X (2021). Advances in SUMO-based regulation of homologous recombination. Curr Opin Genet Dev. 71:114-119.
Shen M, Dhingra N, Wang Q, Gong X, Xu X, Niu H, Zhao X, Xiang S (2021). Structure of Rad5 provides insights into its role in tolerance to replication stress. Mol Cell Oncol. 8(2):1889348.
Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X (2021). The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A. Feb 23;118(8):e2020185118.
Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian , Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X, Xiang S (2021). Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nature Commun. 12: 321.
Whalen JM, Dhingra N, Wei L, Zhao X, Freudenreich CH (2020). Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association. Cell Rep. 31(6):107635.
Dhingra N, Zhao X (2019). Intricate SUMO-based control of the homologous recombination machinery. Genes Dev. 33(19-20):1346-1354.
Dhingra N, Wei L, Zhao X (2019). Replication protein A (RPA) sumoylation positively influences the DNA damage checkpoint response in yeast. J Biol Chem. 294(8):2690-2699.
Dhingra N, Zhao X (2017). SUMO Teams Up with a Translocase to Save TOPO. Mol Cell. 66(5):577-578.
Bruck I, Dhingra N, Martinez MP, Kaplan DL (2017). Dpb11 may function with RPA and DNA to initiate DNA replication. PLoS One.12(5):e0177147.
Dhingra N, Zhao X (2017). A guide for targeted SUMO removal. Genes Dev. 31(8):719-720.
Bruck I, Dhingra N, Kaplan DL (2017). A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase. J Biol Chem. 292(8):3062-3073.
Dhingra, N., Bruck, I., Smith, S., Ning, B., and Kaplan, D.L. (2015). Dpb11 protein helps control assembly of the Cdc45.Mcm2-7.GINS replication fork helicase. The Journal of Biological Chemistry 290, 7586-7601.
Dhingra, N., Kaplan, D.L. (ed) (2016). Introduction to Eukaryotic DNA Replication Inititiation. Springer International Publishing, 1-22.