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Alex Kentsis in his lab
Finding
Research Uncovers the Genetic Causes of Aggressive Leukemia in Children

Researchers have found that the genetic changes that cause pediatric leukemia are different from those that lead to leukemia in adults.
Image of a mobile phone with a strand of DNA
In the Clinic
There’s an App for That: When the Meaning of a BRCA Mutation Isn’t Clear-Cut

A new project called the BRCA Exchange is sharing data about BRCA mutations and what they actually mean for cancer risk.
Memorial Sloan Kettering molecular biologist Jerard Hurwitz
Feature
Remembering Jerard Hurwitz, a Giant of Molecular Biology

MSK colleagues pay tribute to molecular biologist Jerard Hurwitz’s scientific accomplishments and passion for discovery.
MRI of brain and spinal fluid in green
In the Clinic
Analyzing Spinal Fluid Could Guide Brain Tumor Diagnosis and Treatment

Cancer DNA taken from spinal fluid could serve as a liquid biopsy that provides information on brain tumor mutations.
Tumor mutation model
Finding
Tumor Mutational Burden Can Help Predict Response to Immunotherapy in Many Different Cancers

Investigators confirmed that people whose tumors have a high tumor mutational burden and were treated with immunotherapy lived longer.
Side-by-side pictures of tissues from a responder and a non-responder to targeted therapy for kidney cancer
Finding
For Kidney Cancer, the Tumor’s Environment May Be Key to Optimizing Treatment

One size does not fit all when it comes to treating renal cell carcinoma.
2018
Roundup
Top 10 Stories of 2018, Cancer Research Edition

Take a look back at some of the year’s biggest news in cancer research.
electron micrograph of a natural killer cell
In the Lab
Drugs That Stall — But Don’t Kill — Cancer Cells Are an Untapped Resource, Study Suggests

A drug combination that halts tumor cell division can stir the immune system into taking action.
Illustration of mechanical arms altering a cell
In the Lab
MSK Scientists Fine-Tune CAR T Cells to Improve Their Performance

The updated versions can survive longer in the body while still packing a punch against cancer.
a cabinet full of yellow rubber duckies and one blue one
In the Lab
The Immune System Can Fight Cancer. So Why Doesn’t It?

New research from scientists at the Sloan Kettering Institute helps explain how growing tumors escape our immune defenses.