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16 News Items found
In the Lab
An illustration of sugar being sprinkled on a cancer cell.
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
Finding
An illustration of a magnifying glass over a brain.
Study Reveals a New Way That Stress and Aging Lead to Alzheimer’s

A targeted approach being developed to treat certain cancers may also be effective for Alzheimer’s disease.
In the Lab
Epithelial cells
Mind the Gap: Scientists Learn How Cells Make and Repair Tight Connections

New findings from researchers at the Sloan Kettering Institute provide insight into a fundamental biological process called the epithelial-mesenchymal transition.
In the Lab
Illustration of how PU-PET localizes to tumors
Bull’s-Eye: Imaging Technology Could Confirm When a Drug Is Going to the Right Place

Collaborative team advances a new approach for imaging a drug that’s been developed to stop cancer growth.
In the Lab
Two clusters of colored blobs with a diagram in the middle
Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.
Science Byte
Ribbon diagram of an anthrax protein.
Scientists Discover Keys to Immune Response against Anthrax

Researchers clarify how the immune system activates an inflammatory defense against pathogens.
Feature
Memorial Sloan Kettering molecular biologist Jerard Hurwitz
Remembering Jerard Hurwitz, a Giant of Molecular Biology

MSK colleagues pay tribute to molecular biologist Jerard Hurwitz’s scientific accomplishments and passion for discovery.
In the Lab
Left-handed and right-handed KRas molecules
Mirror-Image Chemistry Enables New Approach for Targeting an “Undruggable” Cancer-Causing Protein

MSK chemists are focusing on developing small-molecule drugs to target KRas, an important cancer protein.
In the Lab
Image of fireball-type explosion on black background.
Researchers Gain Insight into How a Drug Fires Up an Immune Response to Cancer

Scientists have learned that a drug activates a form of highly inflammatory programmed cell death called pyroptosis — a discovery that sheds light on immune function.
In the Lab
Portrait of a live zebrafish with dark patterning around and above the eyes
Uncharted Waters: The Making of a New Cancer Drug

A team of scientists is combining sophisticated chemistry and experiments in zebrafish to develop a new cancer drug that shows early potential against melanoma and metastatic breast cancer.