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Charles Sawyers, Chair of Memorial Sloan Kettering’s Human Oncology and Pathogenesis Program, is widely recognized as someone who is revolutionizing the molecular treatment of cancer.

We have identified altered cellular metabolism as a fundamental driver of T-cell exhaustion (Vardhana et al, Nat Immunol 2020). We now aim to understand the specific mechanisms by which T-cell metabolism becomes altered, and how the resultant metabolic alterations activate the global exhaustion program.