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Physician-scientist Yu Chen studies the role of transcription factors that are critical for prostate cancer development.

DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester bonds. We aim to elucidate the structures and catalytic mechanisms of DNA ligases from diverse taxa, especially the basis for nick sensing.

A team of Memorial Sloan Kettering scientists has come up with an approach to make stem-cell-derived neurons rapidly age in a cell culture dish. The breakthrough could transform research into Parkinson’s and other late-onset diseases.