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The Tobias Walther Lab
The Alexander Rudensky Lab
The Benjamin Greenbaum Lab
The Tuomas Tammela Lab
The Steven Larson Lab
The Kenneth Marians Lab
Our chromosomes are much longer than the space in which they are packaged in the cell. Chromosome compaction is on the order of several thousand fold, yet these chromosomes have to be unraveled every cell cycle to be replicated accurately and the daughter chromosomes must be topologically unlinked to allow their separation and segregation into the daughter cells. Management of chromosome shape and topology in bacteria falls to three groups of proteins: the DNA topoisomerases, the structural maintenance of chromosome proteins (SMC), and the small double-strand DNA-binding nucleoid-associated proteins.
The Ross Levine Lab
The Kenneth Offit Lab
The Yu Chen Lab