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Donor T cells are reactive against and effective in adoptive immunotherapy of Epstein-Barr virus (EBV) lymphomas, which develop in some leukemia patients after marrow transplantation. Such T cells have been genetically modified by incorporation of a replication-incompetent vector (NIT) for an inactive mutant nerve growth factor receptor (LNGFR) as an immunoselectable surface marker and a herpes simplex virus thymidine kinase gene (HSV-TK), rendering the cells sensitive to ganciclovir.

Memorial Sloan Kettering’s partnership in a pioneering effort to speed the development of cancer immunotherapies drew national headlines.