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Gerstner Sloan Kettering Core Course Topics

Fall Semester

Section I – Genome Biology and Proteins Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Chromosome structure
  • Cancer as a disease
  • Nature of mutations
  • Forward and reverse genetics
  • Linkage analysis
  • Protein structure, folding and modification
  • Protein structure-function analysis
  • Protein-protein interactions
  • Protein-nucleic acid interactions
  • Topoisomerases and the effects of DNA topology
  • Topoisomerase poisons and nucleoside metabolism effectors as chemotherapeutic agents
  • Drug discovery and development
  • Chromosome replication
  • DNA repair
  • Double-strand break repair and genome editing: Cas9 and other tools
  • Meiotic recombination
  • Biochemical mechanisms of homologous recombination
  • Detecting Chromosomal Structural Rearrangements 
Section II – Gene Expression Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • RNA modification
  • Transcription
  • Epigenetics
  • Translation
  • RNAi and miRNAs
  • Measurement of gene expression
  • Gene transfer vectors: experimental and medical applications
  • Computational and systems biology
  • Methods of experimental perturbation of gene expression and function in culture
  • Mouse model systems
  • Clinical manipulation of gene expression
  • Errors in protein folding and cancer
Section III – Cell Biology and Cell Cycle Control Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Visualization of cells and cellular components
  • Voltage gated channels
  • Cellular membrane structure and function I
  • Cytoskeletal architecture
  • Chemotaxis and Cell Migration
  • Cellular membrane structure and function II
  • Endoplasmic reticulum and endocytic trafficking
  • Mitochondria and endoplasmic reticulum
  • The cell cycle (G1 decisions)
  • The cell cycle (S-phase, once and only once per cycle)
  • Chromosome segregation and cell division
  • The mitotic checkpoint
  • Centrosome
  • p53
  • The DNA damage response
  • Chemical biology and chemotherapy of mitotic poisons
  • Programmed cell death
  • Cell cycle checkpoints and chemotherapy
  • Phase I design principles
  • Radiation as a therapeutic agent

Spring Semester

Section IV – Development, Stem Cells and Morphogenesis Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Introduction to developmental biology
  • Preimplantation mouse development, cell lineages, and manipulation of the mouse genome in ES cells; basic tools of mouse molecular genetics
  • Gastrulation and early morphogenesis in mammals
  • Neural Development (cell polarity and migration)
  • Gastrulation and early morphogenesis in Drosophila
  • Lineage and cell polarity in development
  • The Ras and MAP kinase pathways: normal functions in development
  • The Ras and MAP kinase pathways in disease
  • TGFβ signaling pathways in development
  • TGFβ signaling pathway in developmental disorders, inflammation and cancer
  • Hedgehog in development
  • Hedgehog and cancer
  • Wnt—the pathway and its normal functions in development (canonical and non-canonical pathways)
  • Wnt and cancer
  • Notch
  • Cell migration and invasion
  • Growth regulation: PI3K and Hippo pathways in development
  • Akt and mTor in cancer
  • Crosstalk between signaling pathways
  • Epigenetic regulation in development
  • Cell-to-cell adhesion and communication
  • Cell matrix adhesion and signaling
  • Stem Cells
  • Stem Cells and human development
Section V – Immunology Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Overview: molecules, cells and tissues
  • Innate immunity
  • Cytokines and chemokines
  • NK cels and receptors
  • MHC and antigen presentation
  • Rearrangements of antigen receptor genes
  • B cell differentiation
  • Lymphocyte activation
  • T cell differentiation
  • Tolerance and autoimmunity
  • Tumor immunity I: lymphoid architecture and recirculation
  • Tumor immunity II
  • Tumor immunity III
  • Biostatistics
Section VI – Cancer Biology Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Cancer Genomics
  • Principles of biomarkers
  • Learning from Extraordinary Responders
  • Pathology slide review
  • Cancer metabolism
  • DNA Methylation and Oncogenic Transformation
  • Acute Myeloid Leukemia
  • Functional Genomics
  • Lymphoid Malignancies
  • Glioblastoma Multiforme
  • Computational Biology Lab Exercise
  • Thyroid Cancer-Mouse Models, Kinase Inhibitors, Determinants of Response and Mechanisms of Intrinsic Resistance
  • Sarcomas
  • Leukemia Stem Cells
  • Breast cancer and Targeted Therapies
  • Prostate cancer-translocations
  • Drug resistance
  • Cancer susceptibility
  • Kidney cancer
  • Genotype-directed clinical trials