Core Course

During the first year, this course meets three hours daily for 16 weeks during the fall and spring semesters. Topics are presented through a mix of didactic lecture and discussion focused on research papers. Students are expected to present papers and lead conversations in which the group analyzes publications.

The course is divided into six sections:

  • Genome Biology and Proteins, including genes and gene organization, chromosome biology, the maintenance of genomic integrity, and methods of manipulating genes
  • Gene Expression, including proteins and their synthesis, enzymes and their mechanisms, protein structure and function, and regulation of gene expression
  • Cell Biology and Cell Cycle Control, including cellular organization, cell cycle control, and cellular response to external and internal stimuli
  • Signaling and Development, including cell signaling pathways and mechanisms, cell differentiation, tissue formation, and organ development
  • Cancer Immunology, including antigen processing and presentation, innate and cognate immunity, immune surveillance, leukemia, and lymphoma
  • Cancer Biology, including the nature of evidence-based medicine, imaging, cancer metabolism, cancer genomics, cancer epigenetics, cancer susceptibility, kinase inhibitors, and model systems

Observing in the Clinic

An important aspect of integrating basic and clinical sciences is developing an appreciation of the human side of disease, observing real-life challenges faced by clinical practitioners, and understanding the gap between a good research idea and its execution in the clinic. During the first year of the program, students visit various clinics as observers.

Laboratory Rotations

Students complete three five-week laboratory rotations during the first year. Students choose their first rotation in consultation with their first-year mentor and the dean prior to their arrival on campus. The first-year mentor provides guidance for selecting the second and third rotations as well.

These rotations provide students with an opportunity to get to know the faculty, students, and postdocs in the laboratory. There is no coursework during the rotations, allowing students to focus on developing an appreciation for the ongoing research, the style and approach of the principal investigator, and the personality and dynamics of the laboratory, as well as ideas for potential thesis projects.

Students prepare a two-page written summary at the end of each rotation, and give a ten-minute summary presentation to an audience of fellow students, first-year mentors, and rotation mentors. Each student’s performance in the rotation is assessed via a written evaluation by the rotation mentor in discussion with the student.

Logic and Critical Analysis

All first-year students complete this course during the first rotation period. Scientific papers are used to help set the foundation for students to develop their ability to think logically, critically analyze information and data, and present scientific results to a group.

Students are encouraged to develop an approach to understanding the scientific literature, which includes asking the following questions about each experiment: What is the question the authors asked? How was the experiment performed? What techniques were used and why? What is the nature of the data produced? What represents a significant result? What were the conclusions made by the authors? Does the authors’ data justify the conclusions made? What conclusions would the student make?

Responsible Conduct of Research

All students are required to complete this course in the fall semester of the first year. It provides formal training related to issues of research integrity.

The goals of this course are to:

  • heighten the awareness of trainees to ethical considerations relevant to conducting research
  • inform trainees of federal, state, and institutional policies, regulations, and procedures applicable to conducting ethical research
  • provide trainees with the opportunity to engage with senior faculty and peers, in a relatively informal setting, about the implications of policies and procedures on their behavior in a research environment

President’s Research Seminar Series Journal Club

All students complete two semesters of this course during the first year. The President’s Research Seminar Series brings some of the most-distinguished scientists in the world to Memorial Sloan Kettering. The topics presented include some of the most exciting recent developments in modern biology.

Students participate in a journal club the day before the President’s Research Seminar Series meets, in order to review some of the speaker’s published work, and they meet with the speaker on the day of the seminar.

Quantitative Biology

This course, co-taught with the Weill Cornell Graduate School, will prepare students to apply quantitative techniques to the analysis of experimental data. To emphasize both practical and theoretical skills, the course will involve several hands-on workshops, and the completion of several projects by the students will be required.

Specific topics include:practical aspects of data formatting and management; graphical, mathematical, and verbal communication of quantitative concepts; a review of statistics, with emphasis on the selection of appropriate statistical tests, the use of modern software packages,  the interpretation of results,  and the design of experiments; and the formulation, evaluation, and analysis of mathematical models of biological function, with an emphasis on linear and non-linear regression,  determination of model parameters, and the critical comparison of alternative models with regard to over-parameterization.

Course Topics

  • Quantifying a sample distribution
  • Probability density functions and the normal distribution
  • Practical R (part I), introduction and common data structures
  • Confidence intervals and contingency tables
  • p-Values and formal statistical testing
  • Practical R (part II), libraries and ggplot, data driven graphics
  • Statistical power and experimental design
  • Practical R (part III), control structures and programming
  • Multiple hypothesis testing and non-parametric tests
  • Bayesian methods
  • Correlation vs. linear regression
  • Fitting model parameters to data
  • Practical R (part IV), data wrangling with melt, cast, and plyr
  • Quantitative comparison of models

Graduate Student Seminar

An important feature of becoming a successful scientist is the ability to present the results of your research in a coherent and logical form.

From the second year on, all students in the program are required to attend and participate in the graduate student seminar. Each student presents his or her project, and fellow students provide critical feedback.

Current Topics Journal Club

Students participate in this weekly course beginning in the second year and continuing throughout their tenure in the graduate program. Divided into small groups, students select papers of interest and present them to the group for discussion.

A journal club of this type is important in that it helps prevent the tunnel vision that can sometimes develop as students focus on their thesis research. Because the entire student body participates, the forum includes diverse topics and a continued exchange of ideas within the graduate community.

Clinical Apprenticeship

The goal of the Clinical Apprenticeship is to inspire and encourage students to think about solutions to clinical challenges using their basic science knowledge. The apprenticeship also helps students learn the clinical landscape, so they can have meaningful scientific exchanges with clinicians.

These goals are met via student engagement with a clinical mentor (CM), a unique component of our educational program. The CM is a member of the Memorial Hospital attending staff who is involved in patient-oriented research. Selection of a CM is guided in large part by the student’s research project.

For example, a student studying meiosis might have a CM who studies and treats patients with germ cell tumors. Similarly, a student studying the Wnt signaling pathway might have a CM who studies and treats patients with colon cancer.

This clinical perspective is best achieved through a series of informal meetings over a period of two years (years three and four in the graduate program), in which CMs share experiences, bring students to clinical visits, and identify pressing challenges in their areas of expertise.

CMs guide students in attending various hospital-based academic activities such as grand rounds, residents’ reports, Specialized Programs of Research Excellence (SPORE) and program project meetings, and disease management team conferences that can help the student appreciate current clinical issues, and provide opportunities to learn more about the specific clinical discipline.