Core Course Topics

Core Course Topics

A 3D printed model of a lung from MSK's Biomedical Engineering Service.

A 3D printed model of a lung from MSK's Biomedical Engineering Service.

Fall Semester 


Section I — Experimental Biology 


  • Imaging at different scales 
  • Physics of converting a 3D object into a 2D image 
  • Electron microscopy 
  • Light microscopy 
  • Whole body imaging 


  • Nature and types of mutations 
  • CRISPR techniques and application 
  • Forward and reverse genetics 
  • Drosophila model systems 
  • Mouse genetics 


  • Molecular techniques for the analysis of DNA, RNA, and protein 
  • Protein production and purification 
  • Post-translational modifications 
  • Protein-nucleic acid interactions 


  • Basic overview of genomes 
  • Technology platforms for genomics 
  • Sequencing techniques and approaches 
  • Library construction 
  • Single-cell analyses 

Quantitative and Computational Biology: 

  • Overview of Unix and R 
  • Review and plotting of TCGA data 
  • RNA-seq 
  • Single-cell RNA-seq 
  • ChIP-seq  
Section II — Cancer Engineering 

Molecular and Nanoengineering 

  • drug delivery 
  • nanomaterials 
  • instrumentation 
  • tissue engineering 

Cancer Imaging 

  • Optical (microscopy and intravital) 
  • Acoustic (including ultrasound) 
  • Nuclear imaging (PET, SPECT, and CT) as well as magnetic resonance imaging (MRI/MRS). 

Genetic Engineering 

  • Tools and concepts that can be applied to laboratory research.  
  • Benefits and risks 
  • Latest research and technologies advancing the science of genetic principles explored during the Experimental Biology course  

Spring Semester


Section III — Immunology  
  • Cellular, molecular, and biochemical aspects of the immune system 
  • How immune responses function in physiology.  
  • Development of the immune system and the biological functions of its major components.  
Section IV — Entrepreneurship  
  • Understanding intellectual property 
  • Evaluating the market for a technology 
  • Building a basic financial model 
  • Establishing funding mechanisms 
  • Assessing regulatory issues 
  • Developing a business plan.  
Section V —  Cancer Biology
  • Cancer as a disease 
  • Genetic mechanisms 
  • Cancer signaling 
  • Computational biology and oncology 
  • Cancer metabolism 
  • Tumor heterogeneity 
  • Cancer modeling 
  • Tumor microenvironments 
  • Metastasis 
  • Targeted therapies 
  • Immunotherapy