Molecular Biology Program

The Simon Powell Lab

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Research

Simon N. Powell, MD, PhD
Simon N. Powell, MD, PhD


Professor

The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically. 

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Powell Lab Logo
The Powell lab researches how normal cells become cancerous by studying how genome integrity is maintained.

The Powell lab researches how normal cells become cancerous by studying how genome integrity is maintained.

Super-resolution microscopy of DNA end-resection at radiation-induced double-strand breaks.

Super-resolution microscopy of DNA end-resection at radiation-induced double-strand breaks.

Members of the Simon Powell Lab

Members of the Simon Powell Lab

Featured News

Radiation Oncology Department Chair Simon Powell
At Work: Radiation Oncology Department Chair Simon Powell

Radiation oncologist Simon Powell eagerly tackles the challenge of translating discoveries from the laboratory to the clinic as effectively as possible.
Science Byte
Blue cells containing small red dots on a green and black background
Lifeguard on Duty: Looking at DNA Repair under a Microscope

Learn about what DNA repair looks like under a microscope.
Profile
Simon Powell
Meet Radiation Oncologist Simon Powell

Simon Powell leads the Department of Radiation Oncology and focuses in his research on the treatment of breast cancer, including the role of DNA repair deficiencies in breast cancer and breast cancer genetics.

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Publications

Moore, G. et al. Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer. Mol. Cancer Res. 20, 1061–1070 (2022)

Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)

Setton, J., Reis-Filho, J. S. & Powell, S. N. Homologous recombination deficiency: how genomic signatures are generated. Curr. Opin. Genet. Dev. 66, 93–100 (2021). Review.

Setton, Zinda, Riaz, Durocher & Zimmermann. Synthetic Lethality in Cancer Therapeutics: The Next Generation Cancer Discov. (2021). Review

Samstein, R. M. et al. Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy. Nat Cancer 1, 1188–1203 (2021)

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People

Simon N. Powell, MD, PhD

Simon N. Powell, MD, PhD



Professor

  • Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.
  • PhD, MD, University of London
[email protected]
Email Address
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Physician profile

Members

Erika Buechelmaier
Erika Buechelmaier

Weill-Cornell Graduate Student

Manisha Jalan
Manisha Jalan

Research Scholar

Niamh McDermott
Niamh McDermott

Research Fellow

Jeremy Setton
Jeremy Setton

Instructor

Robert Delsite, PhD
Robert Delsite

Senior Research Scientist

Simon Powell, MD, PhD
Simon Powell

Chairman Attending

Lab Alumni
Sena Ahmed-Seghir
Sena Ahmed-Seghir

Research Scholar

Devi Annamalai

Research Fellow

Cristian Cleary

Research Technician

Gesa Junge
Gesa Junge

Research Fellow

Kyrie Olsen
Kyrie Olsen

Research Technician

Isabella Pecorari
Isabella Pecorari

Research Technician

Nadeem Riaz

Resident

Samantha Sheppard

Research Fellow

Shyamal Subramanyam
Shyamal Subramanyam

Research Fellow

Marcher Thompson

Graduate Research Assistant

Giana Bernheim

Research Technician

Ranjit Bindra

Resident

Alison Carley

Graduate Student

Jarin Chun

Research Fellow

Laura Eccles

Research Fellow

Alex Goglia

Research Technician

Benjamin Lok

Graduate Research Assistant

Robert Mutter

Resident

Ciara O'Driscoll

Research Fellow

Rohini Roy

Research Fellow

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Postdoctoral Research Fellow in Molecular Biology/Radiation Oncology

There are currently two postdoctoral research fellow positions available within the laboratory of Simon Powell.

Apply now

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Simon N. Powell discloses the following relationships and financial interests:

  • PharmaPier US LLC
    Provision of Services (uncompensated)
  • Rain Therapeutics Inc.
    Provision of Services
  • Varian Medical Systems
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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