Structural Biology Program
The Richard Hite Lab
Our research group has two primary focuses. One part of the lab focuses on determining the mechanisms of intracellular ion and metabolite transport, while the second studies protein nucleic acid interactions that are critical for maintaining genomic integrity. We study these fundamental processes using a variety of cell biological, biochemical, structural and biophysical tools including cryo-electron microscopy and electrophysiology.
Paknejad N and Hite RK. “Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3.” Nat Struct Mol Biol. 2018. 25:660-668.
Oh S, Paknejad N and Hite RK. “Gating and Selectivity Mechanisms for the Lysosomal K + Channel TMEM175.” eLife. 2020. 9:e53430.
Richard Hite, PhD
- The Hite laboratory studies the mechanisms of metabolite transport and the maintenance of genomic integrity.
- BS, Emory University
- PhD, Harvard University
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- Pershing Square Sohn Prize for Young Investigators in Cancer Research
- Josie Robertson Investigator (2017-2022)
- Searle Scholar
- Tri-Institutional Breakout Award for Junior Investigators
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Richard Hite discloses the following relationships and financial interests:
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