Research Project Title:
Harnessing Acoustic Cavitation to Define Molecular and Spatial Therapeutic Windows for Brain Disease
Personal Statement / Research Interests:
My research focuses on developing translational strategies to improve drug delivery for brain tumors while minimizing treatment-related toxicity. I am particularly interested in focused ultrasound, blood–brain barrier modulation, and tumor vascular biology as approaches to enhance therapeutic delivery and advance safer, more effective treatments for patients with central nervous system malignancies.
My research focuses on developing translational strategies to improve drug delivery for brain tumors while minimizing treatment-related toxicity. I am particularly interested in focused ultrasound, blood–brain barrier modulation, and tumor vascular biology as approaches to enhance therapeutic delivery and advance safer, more effective treatments for patients with central nervous system malignancies.
Current Project Details:
My current project investigates transcranial focused ultrasound with microbubbles as a radiation-sparing strategy to enhance drug delivery in medulloblastoma. Using preclinical models, I study whether acoustic cavitation—ultrasound-stimulated microbubble activity—can activate endothelial transport pathways within the tumor vasculature and improve therapeutic penetration without additional radiation exposure. This work seeks to establish a clinically translatable approach to improving drug delivery in brain tumors, with broader potential for other cancers in which vascular barriers limit treatment efficacy.
My current project investigates transcranial focused ultrasound with microbubbles as a radiation-sparing strategy to enhance drug delivery in medulloblastoma. Using preclinical models, I study whether acoustic cavitation—ultrasound-stimulated microbubble activity—can activate endothelial transport pathways within the tumor vasculature and improve therapeutic penetration without additional radiation exposure. This work seeks to establish a clinically translatable approach to improving drug delivery in brain tumors, with broader potential for other cancers in which vascular barriers limit treatment efficacy.