Elizabeth Wasmuth, PhD

Research Scholar

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Elizabeth Wasmuth

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wasmuthe@sloankettering.edu

Dissertation

Structural and Functional Characterization of the RNA Exosome from S. cerevisiae (2015)

Mentor

Christopher D. Lima, PhD

Start Year

2008

End Year

2015

Education

Cornell University

Publications

Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, International SU2C/PCF Prostate Cancer Dream Team, Zheng D, Schultz N, Sawyers CL. (2017) ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Nature 546, 671-675. PMCID: PMC5576182 [Available on 2018-06-29]

Wasmuth EV, Zinder JC, Zattas D, Das M, Lima CD. (2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife 6, pii: e29062. PMCID: PMC5553935

Wasmuth EV, Lima CD. (2017) The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome. Nucleic Acids Res. 45, 846-860. PMCID: PMC5314766

Zinder JC, Wasmuth EV, Lima CD. (2016) Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3. Mol Cell. 64, 734-745. PMCID: PMC5115963

Wasmuth E, Januszyk K, Lima C. (2014) Structure of an Rrp6-RNA exosome complex bound to polyA RNA. Nature,511, 435-9. PMCID: PMC4310248.

Wasmuth E, Lima C. (2012) Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel. Mol Cell, 48, 133-144. PMCID: PMC3472098.

Wasmuth E, Lima C. (2012) Structure and activities of the eukaryotic RNA exosome. Chapter in the book “The Enzymes” 31, 53-75. ISBN: 18746047. Publisher: Elsevier, Editors: Guillaume F. Chanfreau, Fuyuhiko Tamanoi.