Memorial Hospital Research Laboratories
The Jonathan Peled Lab
Research

Assistant Professor
Cancer immunotherapy hold tremendous promise, but durable responses in most disease types are achieved in only a minority of patients. For example, allogeneic hematopoietic-cell transplantation (allo-HCT) is a curative treatment for hematological malignancies, but its success is limited by relapse, graft-vs-host disease (GVHD), or infection. We and others have established that GVHD severity and mortality risk after transplantation are in part dependent on the composition of the intestinal microbiota, yet the mechanisms by which this is mediated remain poorly understood. The Peled laboratory seeks to use human specimens and mouse models to understand how the gut microbiome and host immunity regulate one another and how these relationships might be manipulated to improve immunotherapy for patients with cancer.
Research Projects
Publications
Peled JU et al. Microbiota as a predictor of mortality in allogeneic HCT. N Engl J Med. 2020 Feb 27;382(9):822-834. https://pubmed.ncbi.nlm.nih.gov/32101664/
Stein-Thoeringer CK … Peled JU*, van den Brink MRM.* Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science. 2019 Nov 29;366(6469):1143-1149. https://pubmed.ncbi.nlm.nih.gov/31780560/
People

Jonathan Peled, MD, PhD
Physician-scientist
Assistant Professor
- The Peled lab focuses on cancer immunotherapy.
- MD, PhD, Albert Einstein College of Medicine
- [email protected]
- Email Address
- View physician profile
- Physician profile
Members


Computational Biologist

Administrative Assistant

Senior Research Technician
Lab Affiliations
Achievements
- NHLBI K08
- New Investigator Award from the American Society for Transplantation and Cellular Therapy
- Career Development Award from the Parker Institute for Cancer Immunotherapy
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Jonathan Peled discloses the following relationships and financial interests:
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CSL Behring
Professional Services and Activities -
Fred Hutchinson Cancer Research Center
Professional Services and Activities -
French National Research Agency
Professional Services and Activities -
Keio University
Professional Services and Activities -
MaaT Pharma
Professional Services and Activities
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Postbiotics Plus Research, LLC
Equity; Professional Services and Activities (Uncompensated) -
Seres Therapeutics
Intellectual Property Rights -
Tufts Medical Center
Professional Services and Activities -
Westchester Medical Center
Professional Services and Activities
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].