Structural Biology Program

The Jonathan Goldberg Lab

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Research

Jonathan Goldberg, PhD
Jonathan Goldberg, PhD
Stephen and Barbara Friedman Chair

Professor

Our research group studies the mechanisms of protein trafficking and quality control at the endoplasmic reticulum (ER) in mammalian cells. A major focus of research is on the COPII protein machinery responsible for synthesis of ER-derived transport vesicles. We are exploring the mechanisms utilized by COPII to segregate folded protein cargo from unfolded forms and ER chaperones. We are exploring the coordination of this process with quality control systems that evaluate the folded state. A second focus of research is the cellular response to ER proteotoxicity arising in neurodegenerative disorders such as Parkinson’s disease, in cancer, and in insulin resistance. We are studying the protective cellular pathways that detect and clear toxic misfolded proteins via ER and post-ER degradative routes.

 

COPII protein machinery model

Publications

Ma W, Goldberg E, Goldberg J. ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate. Elife. 2017, 6:e26624.

Ma W, Goldberg J. TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. Proc Natl Acad Sci USA. 2016, 113: 10061-10066.

Ma W, Goldberg, J. Rules for the recognition of dilysine retrieval motifs by coatomer. EMBO J. 2013, 32: 926-937.

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People

Jonathan Goldberg, PhD

Jonathan Goldberg, PhD

Stephen and Barbara Friedman Chair

Professor

  • The Goldberg laboratory focuses on structural and biochemical characterization of intracellular vesicle transport.
  • PhD, Imperial College (London)
[email protected]
Email Address
212-639-6712
Office Phone

Members

Guoqi Niu
Guoqi Niu
Shun Zhao
Shun Zhao

Research Fellow

Jonathan Goldberg
Jonathan Goldberg

Member

Chen Li
Chen Li

Research Assistant

Wenfu MA, PhD
Wenfu MA

Research Associate

Denise Ramirez
Denise Ramirez

Administrative Assistant

Lab Alumni
Gabriella Angiulli

Research Fellow

Taylor Manett

Research Technician

Narcisa Martinez

Research Fellow

Lab Affiliations

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Jonathan Goldberg discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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