Human Oncology & Pathogenesis Program
The Joe Chan Lab
Research
![Joe Chan](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/287791/main_image/chan-joseph-240319-01_rtc_1200x800.jpg?h=10d202d3)
Assistant Professor
The Joe Chan Lab combines machine learning with disruptive single-cell sequencing and multiplex spatial imaging to study lineage plasticity in cancer, with a particular focus on histological transformation, as a mechanism of acquired resistance, immune escape, and metastasis. The lab has a special interest in quantifying plasticity across space, time, and cancer types.
![Joe Chan Lab](https://www.sloankettering.edu/sites/default/files/node/287791/images/chan-lab-group-240319-02_rtc_1200x800-1.jpg)
Publications Highlights
Chan JM*, Zaidi S, Love JR, Setty M, Wadosky KM, Gopalan A, Choo Z, Persad S, Choi J, LaClair J, Lawrence K, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris MJ, Mazutis L, Chaligne R, Chen Y, Goodrich DW, Karthaus WR, Pe’er D, Sawyers CL. Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling. Science, Aug 2022; 377(6611): 1180-1191. PMID: PMC9653178.
Chan JM*, Quintanal-Villalonga A, Gao VR, Xie Y, Allaj V, Chaudhary O, Masilionis I, Egger J, Chow A, Walle T, Mattar M, Yarlagadda D, Wang JL, Uddin F, Offin M, Ciampricotti M, Qeriqi M, Bahr A, de Stanchina E, Bhanot UK, Lai WV, Bott MJ, Jones DR, Ruiz A, Baine MK, Li Y, Rekhtman N, Poirier JT, Nawy T, Sen T, Mazutis L, Hollmann TJ, Pe’er D, Rudin CM. Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer Cell, 2021 Nov 8;39(11):1479-1496.e18. PMCID: PMC8628860.
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Manoj P, Donoghue M, Won HH, Chan JM, Ciampricotti M, Chow A, Offin M, Chang JC, Ray-Kirton J, Tischfield SE, Egger J, Bhanot UK, I Linkov, Asher M, Sinha S, Silber J, Iacobuzio-Donahue CA, Roehrl MH, Hollmann TJ, Yu HA, Qiu J, de Stanchina E, Baine MK, Rekhtman N, Poirier JT, Loomis B, Koche RP, Rudin CM, Sen T. Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation. Cancer Discovery, 2021. 11(12):3028-3047. doi: 10.1158/2159-8290.CD-20-1863. PMCID: PMC9437746.
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Ciampricotti M, Chow A, Offin M, Ray-Kirton J, Egger JD, Bhanot UK, Linkov I, Asher M, Roehrl MH, Ventura K, Qiu J, de Stanchina E, Chang JC, Rekhtman N, Houck-Loomis B, Koche RP, Yu HA, Sen T, Rudin CM. Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation. J Hematol Oncol, 2021. 14(1):170. doi: 10.1186/s13045-021-01186-z. PMCID: PMC8520275.
Quintanal-Villalonga A, Chan JM*, Yu HA, Pe’er D, Sawyers CL, Sen T, Rudin CM. Lineage plasticity in cancer: a shared pathway of therapeutic resistance. Nature Reviews: Clinical Oncology, 03/2020. 17(6):360-371. doi: 10.1038/s41571-020-0340-z. PMCID: PMC7397755.
People
![Joe Chan](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/287791/main_image/chan-joseph-240319-01_rtc_1200x800.jpg?h=10d202d3)
Joe Chan, MD, PhD
Assistant Professor
Assistant Professor
- MD, PhD, Columbia University Physicians & Surgeons
- [email protected]
- Email Address
Members
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/288076/main_image/forsyth-britney-240319-04_rtc_1200x800.jpg?h=10d202d3)
![Morgan Lallo](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/entity_type/entity_id/main_image/lallo-morgan-240409-04_rtc_1200x800.jpg?h=10d202d3)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/288056/main_image/marciante-christina-231025-013_rt_1200x800.jpg?h=10d202d3)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/303001/main_image/ryan-riazat-240319-07_rtc_1200x800.jpg)
![Eric Sun](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/299916/main_image/sun-eric-240319-01_rtc_1200x800.jpg?h=10d202d3)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/303711/main_image/wang-xinjun-240319-02_rtc_1200x800.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/288076/main_image/forsyth-britney-240319-04_rtc_1200x800.jpg?h=10d202d3)
Bioinformatics Software Engineer
![Morgan Lallo](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/entity_type/entity_id/main_image/lallo-morgan-240409-04_rtc_1200x800.jpg?h=10d202d3)
Bioinformatics Intern
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/288056/main_image/marciante-christina-231025-013_rt_1200x800.jpg?h=10d202d3)
Administrative Assistant
Medical Student
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/303001/main_image/ryan-riazat-240319-07_rtc_1200x800.jpg)
Postdoctoral Fellow
![Eric Sun](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/299916/main_image/sun-eric-240319-01_rtc_1200x800.jpg?h=10d202d3)
MD/PhD Graduate Student
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/303711/main_image/wang-xinjun-240319-02_rtc_1200x800.jpg)
Assistant Attending
Lab Affiliations
Achievements
- Clinical Investigator Award, K08CA259161, National Cancer Institute (2021-Current)
- Young Investigator Award, American Society of Clinical Oncology & Conquer Cancer Foundation (2021-Current)
- Lung Cancer Research Fellowship, American Association for Cancer Research (2021)
- Harborside Endowed Merit Award, American Society of Clinical Oncology & Conquer Cancer Foundation (2021)
- World Conference on Lung Cancer Early Career Award, International Association for the Study of Lung Cancer (2021)
Read more
- Gerry Fellowship, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center (2020-2021)
- Distinguished Young Investigator Award, EGFR Resisters (2020)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
The laboratory has funding for multiple positions, including graduate students, postdocs, and bioinformatics engineers. Experience in programming is strongly preferred.
Get in Touch
-
Lab Head Email