Epidemiology & Biostatistics

The Ed Reznik Lab

Research

Ed Reznik
Ed Reznik, PhD


Assistant Professor

The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data. We use computational tools to address a basic question: how do tumors adapt their metabolism, the process by which they obtain energy and nutrition from the extracellular environment, to sustain malignancy? Our research draws on data from basic science and clinical practice to understand how metabolic adaptations confer selective advantages to tumors, serve as biomarkers of response and resistance to therapy, and poise tumors for effective targeted intervention.

The lab’s research is equal parts machine learning, data science, and bioinformatics, and is conducted by a multidisciplinary group of quantitative scientists and translationally-minded physicians. We study metabolism in many disease contexts, but also have a unique translational focus on kidney cancer.

Reznik Lab Members

Publications Highlights

Xie AX, Tansey W*, Reznik E*. UnitedMet harnesses RNA-metabolite covariation to impute metabolite levels in clinical samples. Nat Cancer. 2025 Apr 18. doi: 10.1038/s43018-025-00943-0. Epub ahead of print. PMID: 40251399.

Zucker M, Perry MA, Gould SI, Elkrief A, Safonov A, Thummalapalli R, Mehine M, Chakravarty D, Brannon AR, Ladanyi M, Razavi P, Donoghue MTA, Murciano-Goroff YR, Grigoriadis K, McGranahan N, Jamal-Hanjani M, Swanton C, Chen Y, Shen R, Chandarlapaty S, Solit DB, Schultz N, Berger MF, Chang J, Schoenfeld AJ, Sánchez-Rivera FJ, Reznik E*, Bandlamudi C*. Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer. Cell. 2025 Feb 6;188(3):851-867.e17. doi: 10.1016/j.cell.2024.11.010. Epub 2024 Dec 18. PMID: 39701102; PMCID: PMC11922039.

Tang C, Castillon VJ, Waters M, Fong C, Park T, Boscenco S, Kim S, Pekala K, Carrot-Zhang J, Hakimi AA, Schultz N, Ostrovnaya I, Gusev A, Jee J*, Reznik E*. Obesity-dependent selection of driver mutations in cancer. Nat Genet. 2024 Nov;56(11):2318-2321. doi: 10.1038/s41588-024-01969-3. Epub 2024 Oct 28. PMID: 39468367; PMCID: PMC11549034.

Kim M, Gorelick AN, Vàzquez-García I, Williams MJ, Salehi S, Shi H, Weiner AC, Ceglia N, Funnell T, Park T, Boscenco S, O’Flanagan CH, Jiang H, Grewal D, Tang C, Rusk N, Gammage PA, McPherson A, Aparicio S, Shah SP*, Reznik E*. Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes. Nat Genet. 2024 May;56(5):889-899. doi: 10.1038/s41588-024-01724-8. Epub 2024 May 13. PMID: 38741018; PMCID: PMC11096122.

Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E*, Gammage PA*. Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w. Epub 2024 Jan 29. PMID: 38286828; PMCID: PMC11056318.

View All Publications

People

Ed Reznik

Ed Reznik, PhD



Assistant Professor

  • The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data.
  • PhD, Boston University

Members

Sonia Boscenco
Sonia Boscenco

Graduate Student

Venise Jan Castillon

MSK Bridge Program Scholar

Ziad El Bakouny

Medical Oncology Fellow

Yash Khandwala

Research Fellow

Andrea Lopez Sanmiguel

Medical Student

Neil Ruthen
Neil Ruthen

Graduate Student

Anirudh Sridharan
Anirudh Sridharan

Postdoctoral Fellow

Ethan Tse

Graduate Student

Amy Xie
Amy Xie

Graduate Student in the BCMB Allied Program in the Graduate School of Weill Cornell

Lab Alumni
Mark Dawidek

Fellow

Lennert Eismann

Research Fellow

Marc Ganz

Medical Student

Minsoo Kim
Minsoo Kim

Research Scholar

Eric Minwei Liu
Eric Minwei Liu

Research Fellow

Tricia Park
Tricia Park

Computational Biologist I

Lina Posada Calderon

Research Fellow

Katiana Vazquez Rivera
Katiana Vazquez Rivera

Research Fellow

Cerise Tang
Cerise Tang

Research Fellow

David Tourigny
David Tourigny

Affiliated Research Scholar

Mark Zucker
Mark Zucker

Research Scholar

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs