The Alexander Gitlin Lab
The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are tasked with integrating diverse molecular signals from both host and pathogen to produce appropriately commensurate inflammatory responses. Whereas insufficient inflammatory responses can lead to immunodeficiency, overexuberant inflammation can cause devastating collateral tissue damage. We study a set of genes that control the balance between cellular signaling and death and whose deficiencies cause a wide spectrum of severe genetic immune diseases in humans. Focusing on this interconnected network of genes, we use genome editing in primary immune cells, in vivo models, biochemistry, proteomics, advanced imaging techniques, and genomic screens to decipher molecular and cellular pathways that govern inflammation and innate immunity.
Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, Kang J, Pham A, Caothien R, Bacarro N, Hinkle T, Xu M, McKenzie BS, Haley B, Lee WP, Lill JR, Roose-Girma M, Dohse M, Webster JD, Newton K, Dixit VM. Integration of innate immune signalling by caspase-8 cleavage of N4BP1. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub 2020 Sep 24.
Alexander Gitlin, MD, PhD
- The Gitlin Lab studies the molecular and cellular mechanisms underlying inflammatory cell signaling in health and disease.
- MD, Weill Cornell Medicine, Medicine (2017)
- PhD, The Rockefeller University, Immunology (2016)
- NIH Director's DP5 Early Independence Award (2022-2027)
- Josie Robertson Investigator (2022-2027)
- Burroughs Wellcome Fund: Career Award for Medical Scientists (2022)
- National Institute of Allergy and Infectious Diseases (NIAID) K08: Mentored Clinical Scientist Research Career Development Award (2021)
- Harold M. Weintraub Graduate Student Award (2016)
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Alexander Gitlin discloses the following relationships and financial interests:
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