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In the Lab
Pictured: Viviane Tabar
Investigators Use Stem Cells to Study Rare Pediatric Brain Tumors

Investigators have created the first-ever genetically engineered model of cancer made from human embryonic stem cells in culture.
Finding
Michel Sadelain and Prasad Adusumilli
Immunotherapy Shows Promise for Treating Solid Tumors in the Chest

A study in mouse models suggests how modified T cells may be used to treat tumors in the area just outside the lungs.
Finding
MSK investigators Michael Berger and David Solit.
Study Reveals How Some Breast Cancers Become Resistant to Targeted Drugs

A study of one patient’s disease has clarified why tumors stop responding to a class of experimental drugs called PI3K inhibitors.
Decoder
DNA wrapped around histones
What Is Epigenetics?

Physician-scientist Omar Abdel-Wahab explains epigenetics, a growing field based on the study of genetic changes that are not part of the DNA code, and how it relates to cancer.
In the Lab
Pictured: Ping Chi
Molecular Studies Provide New Clues about Rare Soft Tissue Sarcoma

Genetic analysis reveals biomarkers and possible drug targets for malignant peripheral nerve sheath tumors.
In the Lab
Pictured: Experimental Brain Tumor
Genetic “Kill Switch” Could Make Cell Therapies Safer

Researchers have engineered a gene into therapeutic cells that allows them to turn off tumor growth if some of the cells become cancerous.
In the Lab
Stained pathology slides of a patient’s tumor (right) and of an organoid made from that tumor (left).
Prostate Cancer Organoids Provide New Tool for Evaluating Therapies

Researchers have created tiny structures called organoids from patients’ prostate tumors. These organoids will allow the study of tumors in greater detail and enable correlation of genetic mutations with drug response.
Finding
Pictured: Gabriela Chiosis
Hsp90: A Very Promising Target for Cancer Therapy

A small molecule discovered at MSK called PU-H71 blocks the growth of cancer cells and enables doctors to image tumors.
Feature
Memorial Sloan Kettering is transforming our understanding and treatment of cancer in a myriad of ways.
Memorial Sloan Kettering Transforms Cancer Research and Care Delivery

Memorial Sloan Kettering’s vision is nothing less than to revolutionize the treatment of cancer. Learn about some of the ways we’re doing it.
Profile
Pictured: David Solit
At Work: Physician-Scientist David Solit

David Solit, Director of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology, discusses how working with cancer patients drives him to develop more-effective, personalized cancer treatments.