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The Derek Tan Lab
The Michael Kharas Lab
The Daniel Heller Lab
The Stewart Shuman Lab
DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester bonds. We aim to elucidate the structures and catalytic mechanisms of DNA ligases from diverse taxa, especially the basis for nick sensing.
The Cristina Antonescu Lab
The Jan Grimm Lab
The Scott Lowe Lab
The Joan Massagué Lab
The Kenneth Offit Lab
The Joo-Hyeon Lee Lab