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The Sohrab Shah Lab
The Joo-Hyeon Lee Lab
The Marc Ladanyi Lab
The Vinod Balachandran Lab
The Kushal Dey Lab
The Ross Levine Lab
The Joan Massagué Lab
The Scott Keeney Lab
Meiotic recombination is initiated by DNA double-strand breaks (DSBs) generated by the topoisomerase-like Spo11 protein. We are studying the mechanism and regulation of Spo11-dependent DSB formation in the yeast S. cerevisiae, as well as examining the factors that dictate where Spo11 cleaves the DNA and that control the outcome of the recombination process.
News
Memorial Sloan Kettering researchers have discovered that the AR and PI3K disease pathways regulate each other through reciprocal negative feedback.