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Feature
Group photo of researchers Michael Berger, Marc Ladanyi, Dana Tsui, Rose Brannon, Ryma Benayed, Ahmet Zehir, and David Klimstra.
How MSK-ACCESS Blood Test for Cancer was Created

MSK-ACCESS, a blood test that can detect mutations in 129 genes related to cancer, has already helped guide the treatment of more than 2,800 patients at MSK.
Finding
Zsofia Stadler
Knowledge of Inherited Gene Mutations Increasingly Can Guide Cancer Treatment

An analysis of patients who received molecular testing at MSK has found that about half of those with hereditary gene mutations could benefit from treatment with therapies that target those alterations.
In the Lab
Structural biologist Stephen Long in his lab
High-Tech Microscope Reveals Inner Workings of Protein Assembly Machinery

Sloan Kettering Institute investigators have learned how Hedgehog proteins, which are important in both development and cancer, are assembled.
In the Lab
Memorial Sloan Kettering computational biologist Ed Reznik.
Hiding in Plain Sight: Mitochondrial DNA May Hold Overlooked Cancer Clues

DNA in the mitochondria of cancer cells may yield insights that lead to more accurate prognoses and new treatment strategies.
Human metastatic melanoma cells in a lymph node. ENPP1, a protein involved in immune evasion, is shown in green.
Taking the STING Out of Cancer: Discovery about How Cancer Cells Evade Immune Defenses Inspires New Treatment Approach

The research identifies a protein called ENPP1 as a potential drug target in the treatment of advanced cancers with chromosome instability.
Dana Pe'er, Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute
Year in Review: Top 10 MSK Cancer Science Breakthroughs of 2020

Take a look back at some of the biggest cancer science stories from this past year.
Structure of an intermediate during the homologous recombination reaction.
Wielding Powerful Imaging Tools, MSK Researchers Decipher Process of DNA Repair

The high-resolution views provided by cryo-electron microscopy are helping scientists learn how proteins and DNA collaborate to repair broken DNA.
Nadeem Riaz (left) and Jorge Reis-Filho (right)
For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment

Human data and results from mouse experiments suggest that people with BRCA2 mutations may respond well to immunotherapy drugs.
In the Lab
SKI cell biologists Junmei Yi and Xuejun Jiang
More Evidence that Cellular ‘Death by Iron’ Could Be Promising Avenue of Cancer Treatment

Cancers with certain mutations are vulnerable to ferroptosis, a form of iron-dependent cell death.
In the Lab
An illustration of a reel of film
Feature Presentation: 3D Movies of Cell Signaling in Early Development from the Hadjantonakis Lab

Grab your popcorn and pull up a chair for these video shorts of cell signaling in early mouse development.